AS-604850CAS: 648449-76-7
MF: C11H5F2NO4S
MW: 285.2
An ATP-competitive inhibitor of PI 3-kinase γ.

AS-604850 (CAS 648449-76-7)

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Application: An ATP-competitive inhibitor of PI 3-kinase γ
CAS Number: 648449-76-7
Molecular Weight: 285.2
Molecular Formula: C11H5F2NO4S
* Refer to Certificate of Analysis for lot specific data (including water content).

AS-604850 is a potent, cell permeable and ATP-competitive inhibitor of PI 3-kinase γ (PI(3)Kγ). AS-604850 also exhibits selectivity over other PI 3-kinase isoforms. AS-604850 is an inhibitor of PI 3-kinase and PI 3-kinase p55 γ, PI 3-kinase p110 α and PI 3-kinase p85 α.


References

M. Camps, et al.; Nat. Med. 11, 936 (2005). A. Bilancio, et al.; Blood 107, 642 (2006).

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), water (<2 mg/ml), acetonitrile (6 mg/ml), methanol (9 mg/ml), and 100% ethanol.
Storage :
Store at 4° C
Melting Point :
221.07° C (Predicted)
Boiling Point :
518.14° C at 760 mmHg (Predicted)
Density :
1.72 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
PI 3-kinase p110β: IC50 = > 2000 nM; PI 3-kinase p110 δ: IC50 = > 2000 nM; MCP-1-mediated monocyte chemotaxis: IC50 = 21000 nM (rat); PI 3-kinase p110 gamma: IC50 = 250 nM; PI 3-kinase p110α: IC50 = 4500 nM
Ki Data :
PI 3-kinase p110 gamma: Ki= 0.18 µM
pK Values :
pKa: 7.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5287855
MDL Number :
MFCD19705528
SMILES :
C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C/3\C(=O)NC(=O)S3

Download SDS (MSDS)

Certificate of Analysis

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