AS 19A potent SR-7 agonist

AS 19 (CAS 1000578-26-6)

AS 19 | CAS 1000578-26-6 is rated 5.0 out of 5 by 1.
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Synonym: (2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine
Application: A potent SR-7 agonist
CAS Number: 1000578-26-6
Purity: ≥98%
Molecular Weight: 283.41
Molecular Formula: C18H25N3
* Refer to Certificate of Analysis for lot specific data (including water content).
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AS 19 has been reported to be a potent SR-7 agonist (IC50 = 0.83 nM).


References

Sanin et al (2003) 5-Aryl substituted (S)-2-(dimethylamino)-tetralins novel serotonin 5-HT7 receptor ligands. 14th Camerino-Noordwijkerhout Symposium. Ongoing progress in the receptor chemistry. P27. Perez-Garcia and Meneses (2005) Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav.Brain Res. 163 136. Perez-Garcia et al (2006) An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav.Brain Res. 169 83.

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol (100 nM), and DMSO (100 nM).
Storage :
Desiccate at -20° C
Boiling Point :
~413.3° C at 760 mmHg (Predicted)
Density :
~1.1 g/mL (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
Optical Activity :
α20/D -34°, c = 0.89 in chloroform
IC50 :
SR-7 : IC50 = 0.83 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23642275
MDL Number :
MFCD08669663
SMILES :
CC1=C(C(=NN1C)C)C2=C3CC[C@@H](CC3=CC=C2)N(C)C

Download SDS (MSDS)

Certificate of Analysis

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AS 19  Product Citations

See how others have used AS 19. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26269554  Fields, DP. et al. 2015. Journal of neurophysiology. 114: 2015-22.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Yesilyurt et al Yesilyurt et al. (PubMed ID 25917322) used the 5-HT7 receptor agonist, AS 19, to study 5-HT7's role in opioid and non-opioid type stress-induced analgesia. -SCBT Publication Review
Date published: 2015-03-03
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