AS 19 has been reported to be a potent SR-7 agonist (IC50 = 0.83 nM).
Sanin et al (2003) 5-Aryl substituted (S)-2-(dimethylamino)-tetralins novel serotonin 5-HT7 receptor ligands. 14th Camerino-Noordwijkerhout Symposium. Ongoing progress in the receptor chemistry. P27. Perez-Garcia and Meneses (2005) Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav.Brain Res. 163 136. Perez-Garcia et al (2006) An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav.Brain Res. 169 83.
Soluble in ethanol (100 nM), and DMSO (100 nM).
Desiccate at -20° C
~413.3° C at 760 mmHg (Predicted)
~1.1 g/mL (Predicted)
n20D 1.60 (Predicted)
α20/D -34°, c = 0.89 in chloroform
SR-7 : IC50 = 0.83 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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AS 19 Product Citations
See how others have used AS 19. Click on the entry to view the PubMed entry
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Yesilyurt et alYesilyurt et al. (PubMed ID 25917322) used the 5-HT7 receptor agonist, AS 19, to study 5-HT7's role in opioid and non-opioid type stress-induced analgesia. -SCBT Publication Review
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