AS 041164CAS: 1146702-72-8
MW: 249.2
A potent inhibitor of PI 3-kinase.

AS 041164 (CAS 1146702-72-8)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 111ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 5-(1,3-benzodioxol-5-ylmethylene)-2,4-thiazolidinedione
Application: A potent inhibitor of PI 3-kinase
CAS Number: 1146702-72-8
Molecular Weight: 249.2
Molecular Formula: C11H7NO4S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

AS 041164 is a potent inhibitor of PI 3-kinase with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS 041164 shows a pharmacokinetic profile that is similar to the general PI 3-kinase inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS 041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.


1 Hirsch, E., Ciraolo, E., Ghigo, A., et al. Taming the PI3K team to hold inflammation and cancer at bay. Pharmacology & Therapeutics 118 192-205 (2008). 2 Ferrandi, C., Ardissone, V., Ferro, P., et al. Phosphoinositide 3-kinase γ inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. JPET 322 923-930 (2007).

Physical State :
Solubility :
Soluble in DMSO (~25 mg/ml), dimethyl formamide (~25 mg/ml), and 1:9 ethanol:PBS(pH 7.2) (~0.1 mg/ml).
Storage :
Store at -20° C
Melting Point :
224.44° C
Boiling Point :
525.36° C
Density :
1.60 g/cm3
Refractive Index :
n20D 1.73
IC50 :
PI3Kγ : IC50 = 70 nM; PI3Kα: IC50 = 240 nM; PI3Kβ: IC50 = 1.45 µM; PI3Kδ: IC50 = 1.70 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 167ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 20ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.