Arphamenine BCAS: 144110-38-3
MF: C16H24N4O4 0.5 H2SO4
MW: 385.43
A specific aminopeptidase B inhibitor.

Arphamenine B (CAS 144110-38-3)

Arphamenine B | CAS 144110-38-3 is rated 5.0 out of 5 by 1.
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Synonym: 5-amino-8-guanidino-2-(4-hydroxyphenylmethyl)-4-oxooctanoic acid
Application: A specific aminopeptidase B inhibitor
CAS Number: 144110-38-3
Molecular Weight: 385.43
Molecular Formula: C16H24N4O4 0.5 H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Arphamenine B is a bacterial product that acts as a specific aminopeptidase B inhibitor, a metalloprotease. Studies on five different human leukemic cell lines have shown that arphamenine B does not seem to have growth inhibitory effects on these cells.


References

1. Umezawa, H., et al. 1983. J. Antibiot. 36: 1572-1575. PMID: 6654760
2. Fujii, H., et al. 1996. Biol. Pharm. Bull. 19: 6-10. PMID: 8820902
3. Sekine, K., et al. 1999. Leukemia. 13: 729-734. PMID: 10374877
4. Hwang, S.R. and Hook, V. 2008. FEBS Lett. 582: 2527-2531. PMID: 18571504

Appearance :
Powder
Physical State :
Solid
Derived From :
Microbial.
Solubility :
Soluble in water (partly miscible).
Storage :
Store at -20° C
Refractive Index :
n20D ~1.62 (Predicted)
Ki Data :
Aminopeptidase B: Ki= 0.84 nM (rat); Cystinyl aminopeptidase: Ki>0.26 mM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
44134550
SMILES :
C1=CC(=CC=C1CC(CC(=O)C(CCCN=C(N)N)N)C(=O)O)O.C1=CC(=CC=C1CC(CC(=O)C(CCCN=C(N)N)N)C(=O)O)O.OS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Hwang et al Hwang et al. (PubMed ID 18571504) used arphamenine B to inhibit aminopeptidase B activity in order to study zinc regulation of neuropeptide production by aminopeptidase B. -SCBT Publication Review
Date published: 2015-02-16
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