Arphamenine B is a bacterial product that acts as a specific aminopeptidase B inhibitor, a metalloprotease. Studies on five different human leukemic cell lines have shown that arphamenine B does not seem to have growth inhibitory effects on these cells.
1. Umezawa, H., et al. 1983. J. Antibiot. 36: 1572-1575. PMID: 6654760 2. Fujii, H., et al. 1996. Biol. Pharm. Bull. 19: 6-10. PMID: 8820902 3. Sekine, K., et al. 1999. Leukemia. 13: 729-734. PMID: 10374877 4. Hwang, S.R. and Hook, V. 2008. FEBS Lett. 582: 2527-2531. PMID: 18571504
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Hwang et alHwang et al. (PubMed ID 18571504) used arphamenine B to inhibit aminopeptidase B activity in order to study zinc regulation of neuropeptide production by aminopeptidase B. -SCBT Publication Review
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