Arphamenine ACAS: 144110-37-2
MF: C16H24N4O3•1/2H2SO4
MW: 369.43
A potent aminopeptidase B inhibitor reported to also inhibit enkephalin-degrading enzymes in the small intestine.

Arphamenine A (CAS 144110-37-2)

Arphamenine A | CAS 144110-37-2 is rated 5.0 out of 5 by 1.
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Application: A potent aminopeptidase B inhibitor reported to also inhibit enkephalin-degrading enzymes in the small intestine
CAS Number: 144110-37-2
Purity: ≥98%
Molecular Weight: 369.43
Molecular Formula: C16H24N4O31/2H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Arphamenine A is an Aminopeptidase B inhibitor reported to also inhibit enkephalin-degrading peptidases. Research in cardiac fibroblast cells indicates that Arphamenine A decreases production of collagen, which results in the inhibition of lysyl oxidase.


References

1. Umezawa, H., et al. 1983. J. Antibiot. 36: 1572-1575. PMID: 6654760
2. Hazato, T., et al. 1985. Biochem. Pharmacol. 34: 3179-3183. PMID: 3899121
3. Enjoh, M., et al. 1996. Biosci. Biotechnol. Biochem. 60: 1893-1895. PMID: 8987870
4. Lijnen, P.J., et al. 2005. J Renin Angiotensin Aldosterone Syst. 6: 69-77. PMID: 16470485

Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DA8337500
PubChem CID :
16218871
MDL Number :
MFCD00135887
SMILES :
C1=CC=C(C=C1)CC(CC(=O)C(CCCN=C(N)N)N)C(=O)O.C1=CC=C(C=C1)CC(CC(=O)C(CCCN=C(N)N)N)C(=O)O.OS(=O)(=O)O

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Certificate of Analysis

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Arphamenine A  Product Citations

See how others have used Arphamenine A. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 15687497  Díaz-Perales, A. et al. 2005. J. Biol. Chem. 280: 14310-14317.

PMID: # 1679058  Shimamura, M. et al. 1991. J. Biochem. 109: 492-497.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from D az D az-Perales, et. al. (PubMed ID 15687497) found that arphamenine A markedly inhibited AP-O in e. coli bacteria. -SCBT Publication Review
Date published: 2015-04-26
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