ARP 101

ARP 101 (CAS 849773-64-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 85ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: An inhibitor of metalloproteinase-2 (MMP-2)
CAS Number: 849773-64-4
Molecular Weight: 406.50
Molecular Formula: C20H26N2O5S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

ARP 101 is a selective inhibitor of the MMP-2 (metalloproteinase-2 ) and, to lesser extent, MMP-9 (metalloproteinase-9), both of which have been shown to play a role in certain key functions of tumour cells, facilitating metastatic tumour dispersion and angiogenesis, resistance to apoptosis and actication of EGF receptors. Studies of ARP 101 show in vitro inhibition of HT1080 sarcoma cell growth on matrigel. ARP 101 has shown ~250 fold selectivity of MMP-2 over MMP-1 and ~100 fold of MMP-9 over MMP-1.


1. Coussens, L.M., et al. 2002. Science. 295: 2387-2392. PMID: 11923519
2. Rossello, A., et al. 2004. Bioorg. Med. Chem. 12: 2441-2450. PMID: 15080939
3. Tuccinardi, T., et al. 2006. Bioorg. Med. Chem. 14: 4260-4276. PMID: 16483784
4. Page-McCaw, A., et al. 2007. Nat. Rev. Mol. Cell Biol. 8: 221-233. PMID: 17318226

Physical State :
Solubility :
Soluble in DMSO (100 mM), and ethanol (25 mM). Insoluble in water.
Storage :
Desiccate at 4° C
Melting Point :
264.14° C
Boiling Point :
610.34° C
Density :
1.23 g/cm3
Refractive Index :
n20D 1.57
Optical Activity :
α20/D +94°, c = 0.01 in Chloroform
IC50 :
inhibitor of MMP-2 : IC50 = 0.81 nM; inhibitor of MMP-1: IC50 = 486 nM; Matrix metalloproteinase 8: IC50 = 1.6 nM (human); Matrix metalloproteinase-2: IC50 = 0.09 nM (human); Matrix metalloproteinase 12: IC50 = 0.2 nM (human); Matrix metalloproteinase 13: IC50 = 4.1 nM (human)
pK Values :
pKa: 9.17
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

ARP 101  Product Citations

See how others have used ARP 101. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23900029  Gyenge, M. et al. 2013. Life Sci. 93: 441-7.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 81ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.