Molecular structure of ARL 67156 trisodium salt, CAS Number: 160928-38-1
ARL 67156 trisodium salt (CAS 160928-38-1)
See product citations (7)
Alternate Names:
ARL 67156 trisodium salt is also known as FPL 67156.
Application:
ARL 67156 trisodium salt is an CD39 (ecto-ATPase) inhibitor/ATP analog that prevents metabolism of P2 purinoceptor agonists.
CAS Number:
160928-38-1
Purity:
≥98%
Molecular Weight:
785.05
Molecular Formula:
C15H21Br2N5O12P3•3Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ARL 67156 trisodium salt is a newly synthesized analog of ATP which functions as a selective CD39 (ecto-ATPase) inhibitor. In addition, studies suggest that ARL 67156 trisodium salt also acts as a weak antagonist for the purinoceptors P2X and P2T and as an agonist for P2u. A common problem observed in the pharamacological classification of receptors is the susceptibility of antagonists and agonists to enzymatic degradation by the assay tissue used, which ARL 67156 trisodium salt may possibly resolve. It has been reported that ARL 67156 trisodium salt also potentiates the effects of UTP, ATP-γ-S, and ATP on purinoceptors via inhibiting dephosphorylation. Furthermore, it can be used as a probe to determine the action of nucleotides and in the classification of purinoceptors. ARL 67156 trisodium salt has a pIC50 = 4.62 and 5.1 in human blood and rat vas deferens, respectively.
ARL 67156 trisodium salt (CAS 160928-38-1) References
- Effect of the ecto-ATPase inhibitor, ARL 67156, on the bovine chromaffin cell response to ATP. | Drakulich, DA., et al. 2004. Eur J Pharmacol. 485: 137-40. PMID: 14757133
- Effects of cooling and ARL 67156 on synaptic ecto-ATPase activity in guinea pig and mouse vas deferens. | Ghildyal, P. and Manchanda, R. 2004. Auton Neurosci. 115: 28-34. PMID: 15507403
- ATP release through connexin hemichannels in corneal endothelial cells. | Gomes, P., et al. 2005. Invest Ophthalmol Vis Sci. 46: 1208-18. PMID: 15790881
- ATP- and adenosine-induced relaxation of the smooth muscle of the pig urethra. | Werkström, V. and Andersson, KE. 2005. BJU Int. 96: 1386-91. PMID: 16287463
- ATP release and extracellular nucleotidase activity in erythrocytes and coronary circulation of rainbow trout. | Jensen, FB., et al. 2009. Comp Biochem Physiol A Mol Integr Physiol. 152: 351-6. PMID: 19049894
- Biochemical characterization of an ecto-ATP diphosphohydrolase activity in Candida parapsilosis and its possible role in adenosine acquisition and pathogenesis. | Kiffer-Moreira, T., et al. 2010. FEMS Yeast Res. 10: 735-46. PMID: 20584084
- P2X and P2Y Receptors Mediate Contraction Induced by Electrical Field Stimulation in Feline Esophageal Smooth Muscle. | Cho, YR., et al. 2010. Korean J Physiol Pharmacol. 14: 311-6. PMID: 21165330
- ATP hydrolysis pathways and their contributions to pial arteriolar dilation in rats. | Vetri, F., et al. 2011. Am J Physiol Heart Circ Physiol. 301: H1369-77. PMID: 21803949
- A commonly used ecto-ATPase inhibitor, ARL-67156, blocks degradation of ADP more than the degradation of ATP in murine colon. | Durnin, L., et al. 2016. Neurogastroenterol Motil. 28: 1370-81. PMID: 27060478
- Extracellular adenosine 5'-triphosphate concentrations changes in rat spinal cord associated with the activation of urinary bladder afferents. A microdialysis study. | Rocha, JN. 2016. Einstein (Sao Paulo). 14: 541-546. PMID: 28076603
- Extracellular ATP Regulates the Vesicular Pore Opening in Chromaffin Cells and Increases the Fraction Released During Individual Exocytosis Events. | Majdi, S., et al. 2019. ACS Chem Neurosci. 10: 2459-2466. PMID: 30892011
- Shedding Light on the Role of Na,K-ATPase as a Phosphatase during Matrix-Vesicle-Mediated Mineralization. | Sebinelli, HG., et al. 2022. Int J Mol Sci. 23: PMID: 36499456
- Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase. | Crack, BE., et al. 1995. Br J Pharmacol. 114: 475-81. PMID: 7533620
- Enhancement of sympathetic purinergic neurotransmission in the guinea-pig isolated vas deferens by the novel ecto-ATPase inhibitor ARL 67156. | Westfall, TD., et al. 1996. Br J Pharmacol. 117: 867-72. PMID: 8851503
- The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea-pig urinary bladder. | Westfall, TD., et al. 1997. Eur J Pharmacol. 329: 169-73. PMID: 9226410
Inhibitor of:
ATPase, and CD39.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARL 67156 trisodium salt, 5 mg | sc-203521 | 5 mg | $311.00 | |||
| US: Only available in the US | ||||||