Aristoforin is a stable and water-soluble derivative of hyperforin inducing apoptosis. Antitumor agent. Aristoforin also inhibits SIRTs. SIRTs are known to deacetylate histones.
1. Gartner, Michael., et al., 2005. Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent. Chembiochem : a European journal of chemical biology. 6(1): 171-7. PMID: 15593112
2. Gey, Claudia., et al., 2007. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angewandte Chemie (International ed. in English). 46(27): 5219-22. PMID: 17516596
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