AripiprazoleA selective dopamine D2-receptor antagonist showing autoreceptor agonist activity

Aripiprazole (CAS 129722-12-9)

Aripiprazole | CAS 129722-12-9 is rated 5.0 out of 5 by 1.
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Synonym: 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Application: A selective dopamine D2-receptor antagonist showing autoreceptor agonist activity
CAS Number: 129722-12-9
Purity: ≥98%
Molecular Weight: 448.39
Molecular Formula: C23H27Cl2N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Aripiprazole is an anti-psychotic selective D2DR (dopamine D2-receptor) antagonist with dopamine autoreceptor agonist activity. Aripiprazole is an activator of SR-1A.


References

Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in Chloroform and Ethanol
Storage :
Store at -20° C
Melting Point :
134-136° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
60795
SMILES :
C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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Aripiprazole  Product Citations

See how others have used Aripiprazole. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25449598  Brust, TF. et al. 2015. Biochem. Pharmacol. 93: 85-91.

PMID: # 25539635  Brust, TF. et al. 2015. J. Pharmacol. Exp. Ther. 352: 480-93.

Citations 1 to 2 of 2 total

What are the solubilities of this compound in DMSO and MeOH?

Asked by: two2igm05
Thank you for your question. The solubility (at 25ºC) for sc-207300 is as follows: DMSO (90 mg/mL, 200.17 mM), water (<1 mg/mL, <1mM), and ethanol (<1 mg/mL, <1 mM). For any further questions, please contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2016-12-23
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Rated 5 out of 5 by from Various publications cite Aripiprazole as Various publications cite Aripiprazole as a selective dopamine D2-receptor antagonist and activator of SR-1A used frequently as an anti-psychotic. -SCBT Publication Review
Date published: 2015-04-12
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