(-)-ArctiinA lignan derivative that downregulates Bcl-XL and inhibits HIV-1 integrase

(-)-Arctiin (CAS 20362-31-6)

(-)-Arctiin | CAS 20362-31-6 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_10, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202064, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 84ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Application: A lignan derivative that downregulates Bcl-XL and inhibits HIV-1 integrase
CAS Number: 20362-31-6
Purity: ≥98%
Molecular Weight: 534.60
Molecular Formula: C27H34O11
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

(-)-Arctiin is a lignan derivative with antitumor activities acting as a potent inhibitor of HIV-I integrase and Topo II (DNA topoisomerase II). (-)-Arctiin down-regulates anti-apoptotic protein Bcl-XL. (-)-Arctiin has been shown to exhibit phytoestrogenic activity and is an antagonist for platelet activating factor and Ca2+.


References

1. Iwakami, S., et al. 1992. Chem. Pharm. Bull. 40: 1196-1198. PMID: 1394633
2. Moritani, S., et al. 1996. Biol. Pharm. Bull. 19: 1515-1517. PMID: 8951177
3. Vlietinck, A.J., et al. 1998. Planta Med. 64: 97-109. PMID: 9525100
4. Takasaki, M., et al. 2000. Cancer Lett. 158: 53-59. PMID: 10940509
5. Wang, X., et al. 2005. J Chromatogr A. 1063: 247-251. PMID: 15700478
6. Liu, S., et al. 2005. Phytochem Anal. 16: 86-89. PMID: 15881114
7. Kang, K., et al. 2007. Biol. Pharm. Bull. 30: 2352-2359. PMID: 18057725

Appearance :
Powder
Physical State :
Solid
Derived From :
Arctium lappa.
Solubility :
Soluble in DMSO (5 mg/ml), and water (sparingly ).
Storage :
Store at -20° C
Boiling Point :
756.43° C at 760 mmHg (Predicted)
Density :
1.36 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Human herpesvirus 5: IC50 = 16 µM; RAW264.7: IC50 = >300 µM (mouse)
pK Values :
pKa: 12.83 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
100528
MDL Number :
MFCD00870630
SMILES :
COC1=C(C=C(C=C1)C[C@H]2COC(=O)[C@@H]2CC3=CC(=C(C=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)OC)OC

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

(-)-Arctiin  Product Citations

See how others have used (-)-Arctiin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26550018  Shin, HS. et al. 2015. Evidence-based complementary and alternative medicine : eCAM. 2015: 368105.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 82ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from determined that ( determined that (-)-Arctiin greatly decreased adipogenesis in 3T3 L1 cells. -SCBT Publication Review
Date published: 2015-03-20
  • y_2019, m_11, d_10, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202064, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 3ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.