Araguspongin B CAS: 123000-02-2
MF: C28H50N2O2
MW: 446.71

Araguspongin B (CAS 123000-02-2)

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Application: Araguspongin B is a signal transduction messenger that promotes transfer of Ca2+ from intracellular stores
CAS Number: 123000-02-2
Molecular Weight: 446.71
Molecular Formula: C28H50N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Araguspongin B is a compound isolated from Pacific basin sponges with notable vasodilatory properties. It serves as an important signal transduction messenger, acting to promote the transfer of Ca2+ from intracellular stores. Araguspongin B has also been shown to exhibit an antagonizing effect on the calcium-releasing action of inosital 1,4,5-triphosphate at receptor levels in cerebral microsomes. Additionally, araguspongin B is an inhibitor of IP3R.


References

1 Nakagawa, M., Endo, M. Structures of xestospongin A, B, C and D, novel vasodilative compounds from marine sponge, Xestospongia exigua. Tetrahedron Lett 25(30) 3227-3230 (1984). 2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-2

Appearance :
Film
Physical State :
Solid
Solubility :
Soluble in water (slightly), chloroform, ethyl acetate, and methyl acetate.
Storage :
Store at -20° C
Boiling Point :
~564.7° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level: IC50 = 0.6 µM (cerebral microsomes)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

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Certificate of Analysis

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Araguspongin B (CAS 123000-02-2)  Product Citations

See how others have used Araguspongin B (CAS 123000-02-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30117680  J. Cell. Mol. Med. 4688-4699.

Citations 1 to 1 of 1 total
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