Araguspongin BA signal transduction messenger that promotes transfer of Ca2+ from intracellular stores

Araguspongin B (CAS 123000-02-2)

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Application: A signal transduction messenger that promotes transfer of Ca2+ from intracellular stores
CAS Number: 123000-02-2
Molecular Weight: 446.71
Molecular Formula: C28H50N2O2
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Araguspongin B is a compound isolated from Pacific basin sponges with notable vasodilatory properties. It serves as an important signal transduction messenger, acting to promote the transfer of Ca2+ from intracellular stores. Araguspongin B has also been shown to exhibit an antagonizing effect on the calcium-releasing action of inosital 1,4,5-triphosphate at receptor levels in cerebral microsomes. Additionally, araguspongin B is an inhibitor of IP3R.


References

1 Nakagawa, M., Endo, M. Structures of xestospongin A, B, C and D, novel vasodilative compounds from marine sponge, Xestospongia exigua. Tetrahedron Lett 25(30) 3227-3230 (1984). 2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992). 3 Gafni, J., Munsch, J.A., Lam, T.H., et al. Xestospongins: Potent membrane permeable blockers of the inositol 1,4,5-triphosphate receptor. Neuron 19 723-733 (1997).

Appearance :
Film
Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
35026815
SMILES :
C1CCC[C@@H]2CCN3CCC[C@@H]([C@H]3O2)CCCCCC[C@H]4CCN5CCC[C@@H]([C@H]5O4)CC1

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