Arachidonoyl-1-thio-GlycerolCAS: 1309664-54-7
MF: C23H38O3S
MW: 394.6
A thiol analog of 2-arachidonoyl glycerol.

Arachidonoyl-1-thio-Glycerol (CAS 1309664-54-7)

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Application: A thiol analog of 2-arachidonoyl glycerol
CAS Number: 1309664-54-7
Purity: >98%
Molecular Weight: 394.6
Molecular Formula: C23H38O3S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-Arachidonoyl glycerol is an endogenous agonist of the central cannabinoid receptor. It is present at relatively high levels in the central nervous system. Monoacylglycerol lipase hydrolyzes arachidonoyl-1-thio-glycerol to arachidonic acid and glycerol. Arachidonoyl-1-thio-glycerol is a thioester substrate analog of 2-arachidonoyl glycerol that can be utilized for the measurement of monoacylglycerol lipase activity. Hydrolysis of the thioester bond by monoacylglycerol lipase generates a free thiol that reacts rapidly with the Ellman's reagent resulting a yellow product with an absorbance maximum at 412 nm.


References

1. Stella, N., et al. 1997. Nature. 388: 773-778. PMID: 9285589
2. Sugiura, T., et al. 1999. J Biol Chem. 274: 2794-2801. PMID: 9915812
3. Kondo, S., et al. 1998. FEBS Lett. 429: 152-156. PMID: 9650580
4. Dinh, T.P., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 10819-10824. PMID: 12136125
5 Cox, J.W. and Horrocks, L.A. 1981. J Lipid Res. 22: 496-505. PMID: 7240974

Formulation :
A solution in acetonitrile
Physical State :
Liquid
Solubility :
Soluble in ethanol, DMSO, DMF andf PBS pH 7.2
Storage :
Store at -80° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1648, Class 3, Packing group II
PubChem CID :
53394565
SMILES :
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)SCC(O)CO

Download SDS (MSDS)

Certificate of Analysis

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