Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide. It inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase by calmodulin and inhibits calmodulin-stimulated Ca-ATPase activity.
1. Levine, S N., et al., . Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. Journal of cardiovascular pharmacology. 5(1): 151-6. PMID: 6186851
2. De Bruin, M L., et al., 2005. Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death. European heart journal. 26(6): 590-7. PMID: 15637086
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