Aprindine hydrochlorideAn hERG channel blocker

Aprindine hydrochloride (CAS 33237-74-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 122ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: N-(2,3-Dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-1,3-propanediamine hydrochloride
Application: An hERG channel blocker
CAS Number: 33237-74-0
Purity: ≥98%
Molecular Weight: 358.95
Molecular Formula: C22H30N2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide. It inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase by calmodulin and inhibits calmodulin-stimulated Ca-ATPase activity.


References

1. Levine, S N., et al., . Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. Journal of cardiovascular pharmacology. 5(1): 151-6. PMID: 6186851
2. De Bruin, M L., et al., 2005. Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death. European heart journal. 26(6): 590-7. PMID: 15637086

Physical State :
Solid
Solubility :
Soluble in water: >10 mg/mL
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71413
SMILES :
CCN(CC)CCCN(C1CC2=CC=CC=C2C1)C3=CC=CC=C3.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 65ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 3ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.