Apoptosis Activator VII, ApoptozoleA cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70

Apoptosis Activator VII, Apoptozole (CAS 1054543-47-3)

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Application: A cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70
CAS Number: 1054543-47-3
Purity: ≥99%
Molecular Weight: 625.6
Molecular Formula: C33H24F6N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Apoptosis Activator VII, Apoptozole is a cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 μM).


References

1. Williams, D.R. et al. 2008. Angew. Chem. Int. Ed. Engl. 47(39): 7466-7469. PMID: 18729127

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), and ethanol (5 mg/ml).
Storage :
Store at 4° C
Melting Point :
223-225° C
Density :
~1.33 g/cm3 (Predicted)
Refractive Index :
n20D ~1.57 (Predicted)
IC50 :
A549: IC50 = 130 nM; SK-OV-3: IC50 = 220 nM; HCT-15: IC50 = 250 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24894064
MDL Number :
MFCD19443178
SMILES :
COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC

Download SDS (MSDS)

Certificate of Analysis

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