You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
Apoptolidin is a selective polyketide, apoptosis inducer produced by Nocardiopsis mainly inducing cell death in E1A-transformed cells and inhibiting the enzymatic activity of mitochondrial F0F1-ATPase. In addition, studies suggest that apoptolidin isomerizes in solution into isoapoptolidin (sc-202187) within the time frame of most cell-based assays, however isoapoptolidin's ability to inhibit mitochondrial F0F1--ATPase is over 10 fold less effective. Furthermore, studies show that apoptolidin induced apoptosis can be inhibited by BCL-2.
1. Salomon, A.R., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 14766-14771. PMID: 11121076
2. Wender, P.A., et al. 2002. Org. Lett. 4: 3819-3822. PMID: 12599467
3. Wender, P.A., et al. 2006. Org. Lett. 8: 589-592. PMID: 16468718
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.