ApoptolidinAn apoptotic cell death inducer

Apoptolidin (CAS 194874-06-1)

Apoptolidin | CAS 194874-06-1 is rated 5.0 out of 5 by 1.
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Application: An apoptotic cell death inducer
CAS Number: 194874-06-1
Purity: >95%
Molecular Weight: 1129.4
Molecular Formula: C58H96O21
* Refer to Certificate of Analysis for lot specific data (including water content).
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Apoptolidin is a selective polyketide, apoptosis inducer produced by Nocardiopsis mainly inducing cell death in E1A-transformed cells and inhibiting the enzymatic activity of mitochondrial F0F1-ATPase. In addition, studies suggest that apoptolidin isomerizes in solution into isoapoptolidin (sc-202187) within the time frame of most cell-based assays, however isoapoptolidin's ability to inhibit mitochondrial F0F1--ATPase is over 10 fold less effective. Furthermore, studies show that apoptolidin induced apoptosis can be inhibited by BCL-2.


References

1. Salomon, A.R., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 14766-14771. PMID: 11121076
2. Wender, P.A., et al. 2002. Org. Lett. 4: 3819-3822. PMID: 12599467
3. Wender, P.A., et al. 2006. Org. Lett. 8: 589-592. PMID: 16468718

Appearance :
Lyophilized
Physical State :
Solid
Derived From :
Amycolatopsis sp. MST-AS5912
Solubility :
Soluble in ethanol, methanol, DMF, and DMSO.
Storage :
Store at -20° C
Boiling Point :
1108.92° C at 760 mmHg (Predicted)
Density :
1.26 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
apoptosis in E1A-transformed cells: IC50 = 11 ng/ml; F0F1-ATPase: IC50 = 700 nM (yeast)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44403674
SMILES :
C[C@@H]1/C=C(/C=C(/C=C(/C(=O)O[C@@H](C[C@@H]([C@H](CC/C=C(/C=C/[C@H]1O[C@H]2[C@H]([C@@H]([C@H]([C@@H](O2)C)OC)O)O)\\C)O)OC)[C@H]([C@]3([C@@H]([C@H]([C@H]([C@H](O3)C[C@H](COC)OC4C[C@]([C@H]([C@@H](O4)C)O[C@H]5C[C@H]([C@@H]([C@H](O5)C)O)OC)(C)O)C)O)C)O)O)\\C)\\C)\\C

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Apoptolidin  Product Citations

See how others have used Apoptolidin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 11182320  Salomon, AR. et al. 2001. Chem. Biol. 8: 71-80.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Salomon Salomon, et. al. (PubMed ID 11182320) established the following: Apoptolidin induces cell death independent of p53 status; BCL-2 inhibits apoptolidin action; Apoptolidin is dependent on the action of caspase-9; PARP is completely cleaved within 6 hours in mouse lymphoma cells in the presence of this polyketide. Salomon suggests based on these results that apoptolidin may target a mitochondrial protein. -SCBT Publication Review
Date published: 2015-07-07
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