apoC-II Antibody (3E4): sc-293340

apoC-II Antibody (3E4) is an IgG_2a κ mouse monoclonal apoC-II antibody (also designated apoC-II antibody) suitable for the detection of the apoC-II protein of human origin by WB, IP and ELISA. apoC-II Antibody (3E4) is available as the non-conjugated anti-apoC-II antibody. Apolipoproteins are protein components of plasma lipoproteins. The apolipoprotein C gene family encodes four homologous proteins designated apoC-I to -IV, which specifically modulate the metabolism of triglyceride-rich lipoproteins. The human apoC-I gene maps to chromosome 19q13.2 and is expressed primarily in the liver where it is activated when monocytes differentiate into macrophages. The human apoC-II gene maps to chromosome 19q13.2 and encodes a 79 amino acid single chain protein that is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues (5-7). The human apoC-III gene maps to chromosome 11q23 and encodes a protein that may delay catabolism of triglyceride-rich particles by inhibiting lipoprotein lipase and hepatic lipase. The human apoC-IV gene maps to chromosome 19q13.2 and encodes a 127 amino acid protein that is primarily expressed in the liver (9,10).

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References:

1. Insights into apolipoprotein C metabolism from transgenic and gene-targeted mice.  |  Jong, MC. and Havekes, LM. 2000. Int J Tissue React. 22: 59-66. PMID: 10937355
2. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.  |  Mak, PA., et al. 2002. J Biol Chem. 277: 31900-8. PMID: 12032151
3. Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins.  |  Kotite, L., et al. 2003. J Lipid Res. 44: 1387-94. PMID: 12700345
4. Hypertriglyceridemia associated with deficiency of apolipoprotein C-II.  |  Breckenridge, WC., et al. 1978. N Engl J Med. 298: 1265-73. PMID: 565877
5. Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus.  |  Allan, CM., et al. 1995. Genomics. 28: 291-300. PMID: 8530039
6. Identification, characterization, cloning, and expression of apolipoprotein C-IV, a novel sialoglycoprotein of rabbit plasma lipoproteins.  |  Zhang, LH., et al. 1996. J Biol Chem. 271: 1776-83. PMID: 8576182
7. Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice.  |  Allan, CM. and Taylor, JM. 1996. J Lipid Res. 37: 1510-8. PMID: 8827523
8. In vivo footprinting analysis of the hepatic control region of the human apolipoprotein E/C-I/C-IV/C-II gene locus.  |  Dang, Q. and Taylor, J. 1996. J Biol Chem. 271: 28667-76. PMID: 8910501