API-1

API-1 (CAS 36707-00-3)

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Synonym: 4-amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Application: A PKB inhibitor that halts Akt membrane translocation
CAS Number: 36707-00-3
Molecular Weight: 337.29
Molecular Formula: C13H15N5O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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API-1 is a PKB inhibitor. The compound acts by halting Akt membrane translocation through binding the pleckstrin homology domain of Akt. API-1 also inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Both in vivo and in vitro antitumor activity has been observed along with cell arrest and apoptosis in cancer cells with constitutive Akt activity.


References

1. Kim, D., et al. 2010. J. Biol. Chem. 285: 8383-8394. PMID: 20068047

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at -20° C
Boiling Point :
795.77 °C at 760 mmHg (Predicted)
Density :
1.79 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
301081
MDL Number :
MFCD18086904
SMILES :
C1=C(C(=O)C2=C(N1C3C(C(C(O3)CO)O)O)N=CN=C2N)C(=O)N

Download SDS (MSDS)

Certificate of Analysis

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