APHA Compound 8A synthetic HDAC (histone deacetylase) inhibitor

APHA Compound 8 (CAS 676599-90-9)

APHA Compound 8 | CAS 676599-90-9 is rated 5.0 out of 5 by 1.
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Application: A synthetic HDAC (histone deacetylase) inhibitor
CAS Number: 676599-90-9
Molecular Weight: 284.31
Molecular Formula: C16H16N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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APHA Compound 8 is a synthetic HDAC (histone deacetylase) inhibitor. It induces histone hyperacetylation, growth inhibition, and terminal cell differentiation.


References

Mai, A., et al., 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. J. Med. Chem. 46, 512-524, (2003); Mai, A., et al., Binding Mode Analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: A new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. J. Med. Chem. 45, 1778-1784, (2002); Massa, S., et al., 3-(4-Aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. J. Med. Chem. 44, 2069-2072, (2001);

Solubility :
Soluble in DMSO: >10 mg/mL
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57352541
SMILES :
C1=CC(=CC=C1CC2=CC=NC=C2)NC(=O)CCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Johnson Johnson, D. et al. (PubMed 23340162) studied four histone-deacetylase inhibitors (HDACi), viz. trichostatin A, sodium butyrate, APHA Compound 8 and apicidin, and tested them in the human lymphoblastoid TK6 cell line-hosted GADD45a-GFP assay -SCBT Publication Review
Date published: 2015-04-08
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