AP-18AP-18 is a novel and effective TRPA1 channel blocker

AP-18 (CAS 55224-94-7)

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Synonym: 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
Application: AP-18 is a novel and effective TRPA1 channel blocker
CAS Number: 55224-94-7
Purity: 98%
Molecular Weight: 209.7
Molecular Formula: C11H12ClNO
* Refer to Certificate of Analysis for lot specific data (including water content).
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AP-18 is a novel ANKTM1 (TRPA1 channel) blocker (CHO cells, IC50= 3.1 μM; human and mouse cell lines, IC50= 4.5 μM). It blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation.


References

Petrus et al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40. Chen et al (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol.Pain 5 3. Taylor-Clark et al (2009) Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol.Pharmacol. In press.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at room temperature
Melting Point :
45.55° C
Boiling Point :
348.38° C at 760 mmHg
Density :
1.10 g/cm3
Refractive Index :
n20D 1.53
IC50 :
TRPA1 : IC50 = 3.1 µm (human); TRPA1 : IC50 = 4.5 µm (mouse)
pK Values :
pKa: 11.96
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9584673
MDL Number :
MFCD00102250
SMILES :
CC(=CC1=CC=C(C=C1)Cl)C(=NO)C

Download SDS (MSDS)

Certificate of Analysis

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