Antipain, Dihydrochloride CAS: 37682-72-7
MF: C27H44N10O6•2HCl
MW: 677.62
A cathepsin, papain, and trypsin inhibitor.

Antipain, Dihydrochloride (CAS 37682-72-7)

Antipain, Dihydrochloride | CAS 37682-72-7 is rated 5.0 out of 5 by 1.
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Synonym: [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl
Application: A cathepsin, papain, and trypsin inhibitor
CAS Number: 37682-72-7
Purity: ≥97%
Molecular Weight: 677.62
Molecular Formula: C27H44N10O62HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Antipain, Dihydrochloride is a reversible protease inhibitor produced by actinomycetes. Antipain inhibits cathepsin A, B, and D as well as papain, trypsin and trypsin-like serine proteases. Antipain acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 μM.

Usage :
Inhibitory Activity ≥30 U/mg (Trypsin, L-BAPA)
Physical State :
solid
Derived From :
Synthetic
Solubility :
Soluble in water (50 mg/ml), DMSO (5 mg/ml), 1-butanol, 1-propanol, ethanol, and methanol. Insoluble in chloroform, benzene, and hexane.
Storage :
Store at -20° C
IC50 :
papain: IC50 = 0.16 µg/ml; trypsin: IC50 = 0.26 µg/ml; cathepsin A: IC50 = 1.19 µg/ml; cathepsin B: IC50 = 0.59 µg/ml; cathepsin D: IC50 = 125 µg/ml; plasmin: IC50 = >93 µg/ml; chymotrypsin and pepsin: IC50 = >250 µg/ml; papain and some cysteine proteases: IC50 = 300 µM
Ki Data :
calpain I: Ki= 1.4 µM (porcine)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YV9350800
PubChem CID :
16218941
MDL Number :
MFCD00135957
EC Number :
253-631-0
SMILES :
CC(C)[[email protected]@H](C(=O)NC(CCCN=C(N)N)C=O)NC(=O)[[email protected]](CCCN=C(N)N)NC(=O)NC(CC1=CC=CC=C1)C(=O)O.Cl.Cl

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Certificate of Analysis

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Antipain, Dihydrochloride  Product Citations

See how others have used Antipain, Dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28223427  Noguchi, F. et al. 2017. Mol. Cancer Ther. 16: 936-947.

PMID: # 25883214  Gangoda, L. et al. 2015. Oncotarget. 6: 11175-90.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Damasceno Damasceno, et al. (PubMed ID 25822177) used antipain conjugated to Sepharose to separate endogenous kininogenases from CHO-K1 lysate fraction. -SCBT Publication Review
Date published: 2015-06-19
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