Molecular structure of Antipain, Dihydrochloride, CAS Number: 37682-72-7
Antipain, Dihydrochloride (CAS 37682-72-7)
See product citations (2)
Alternate Names:
[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl
Application:
Antipain, Dihydrochloride is a cathepsin, papain, and trypsin inhibitor
CAS Number:
37682-72-7
Purity:
≥97%
Molecular Weight:
677.62
Molecular Formula:
C27H44N10O6•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Antipain, Dihydrochloride is a reversible protease inhibitor produced by actinomycetes. Antipain, Dihydrochloride inhibits cathepsin A, B, and D as well as papain, trypsin and trypsin-like serine proteases. Antipain, Dihydrochloride acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 muM.
Antipain, Dihydrochloride (CAS 37682-72-7) References
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- A flow cytometry-based screening system for directed evolution of proteases. | Tu, R., et al. 2011. J Biomol Screen. 16: 285-94. PMID: 21335599
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- A novel pathway for human endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies. | Allen, KL., et al. 2012. Blood. 119: 884-93. PMID: 22106343
- The structure of classical swine fever virus N(pro): a novel cysteine Autoprotease and zinc-binding protein involved in subversion of type I interferon induction. | Gottipati, K., et al. 2013. PLoS Pathog. 9: e1003704. PMID: 24146623
- Lysosomal membrane permeabilization: carbon nanohorn-induced reactive oxygen species generation and toxicity by this neglected mechanism. | Yang, M., et al. 2014. Toxicol Appl Pharmacol. 280: 117-26. PMID: 25110057
- Folate receptor-targeted and cathepsin B-activatable nanoprobe for in situ therapeutic monitoring of photosensitive cell death. | Tian, J., et al. 2015. Anal Chem. 87: 3841-8. PMID: 25739838
- Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation. | Matias, AC., et al. 2016. Oxid Med Cell Longev. 2016: 6724585. PMID: 27123155
- Metacaspase involvement in programmed cell death of the marine cyanobacterium Trichodesmium. | Spungin, D., et al. 2019. Environ Microbiol. 21: 667-681. PMID: 30585394
- Fluoxetine induces glucose uptake and modifies glucose transporter palmitoylation in human peripheral blood mononuclear cells. | Stapel, B., et al. 2019. Expert Opin Ther Targets. 23: 883-891. PMID: 31637934
- Activatable Photodynamic Therapy with Therapeutic Effect Prediction Based on a Self-correction Upconversion Nanoprobe. | Li, Y., et al. 2020. ACS Appl Mater Interfaces. 12: 19313-19323. PMID: 32275130
- Thrombin rapidly digests adrenomedullin: Synthesis of adrenomedullin analogs resistant to thrombin. | Nishimoto, Y., et al. 2020. Biochem Biophys Res Commun. 529: 778-783. PMID: 32736707
- Multiomic features associated with mucosal healing and inflammation in paediatric Crohn's disease. | Taylor, H., et al. 2020. Aliment Pharmacol Ther. 52: 1491-1502. PMID: 32929796
- Production, purification and characterization of a 50-kDa extracellular metalloprotease from Serratia marcescens. | Salamone, PR. and Wodzinski, RJ. 1997. Appl Microbiol Biotechnol. 48: 317-24. PMID: 9352674
Inhibitor of:
cathepsin A, cathepsin B, cathepsin D, Chymotrypsin, Protease, and Trypsin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Antipain, Dihydrochloride, 5 mg | sc-291907 | 5 mg | $63.00 | |||
Antipain, Dihydrochloride, 25 mg | sc-291907A | 25 mg | $214.00 |