Antimycin A CAS: 1397-94-0
Antimycin A is an antibiotic that induces apoptosis.

Antimycin A (CAS 1397-94-0)

Antimycin A | CAS 1397-94-0 is rated 5.0 out of 5 by 1.
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Alternate Names: Antipiricullin; Virosin
Application: Antimycin A is an antibiotic that induces apoptosis
CAS Number: 1397-94-0
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Antimycin A is an antibiotic that induces apoptosis and inhibits the mitochondrial electron transport chain from cytochrome b to cytochrome C1. Additionally, studies report that antimycin A causes damage to mitochondrial DNA, lipids, and proteins in cells treated with the antibiotic. The compound has been shown to mimic cell-death-inducing Bcl-2 homology domain 3 and has been applied as a reactive oxygen species (ROS) generator to study biological systems. Research indicates that antimycin A inhibits the cell growth of HeLa cells through apoptosis and blocks nitric oxide-induced apoptosis via inhibition of cytochrome C leakage.


References

1. Abidi, S.L. 1982. J. Chromatogr. 234: 187-200. PMID: 7056827

2. Guidarelli, A., et al. 1996. Biochem. J. 317: 371-375. PMID: 8713060

3. Kim, K.M., et al. 2001. Biochemistry. 40: 4911-4922. PMID: 11305906

4. Tzung, S.P., et al. 2001. Nat. Cell Biol. 3: 183-191. PMID: 11175751

5. Dairaku, N., et al. 2004. J. Lab. Clin. Med. 143: 143-151. PMID: 15007303

6. Park, W.H., et al. 2007. J. Cell. Biochem. 102: 98-109. PMID: 17372917

7. Guha, G., et al. 2010. Food Chem Toxicol. PMID: 20854871

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp. Mixture of antimycin A′s.
Solubility :
Soluble in 100% ethanol (50 mg/ml), and DMSO (2 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
162-164° C
Optical Activity :
α20D 79±3, c = 0.9-1.1 in chloroform
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CD0350000
PubChem CID :
14957
Merck Index :
14: 714(A1) & 715 (A3)
MDL Number :
MFCD01779723
SMILES :
CCCCCC[[email protected]@H]1[[email protected]]([[email protected]@H](OC(=O)[[email protected]]([[email protected]](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C

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Certificate of Analysis

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Antimycin A (CAS 1397-94-0)  Product Citations

See how others have used Antimycin A (CAS 1397-94-0). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 20 total

PMID: # 30746686  2019. J. Cell. Physiol.

PMID: # 31353872  2019. Physiol Rep. 7: e14193.

PMID: # 27827795  Lee, MY. et al. 2017. EMBO Rep. 18: 48-60.

PMID: # 28848034  Minowa-Nozawa, A. et al. 2017. EMBO J.

PMID: # 29078279  2017. Proc. Natl. Acad. Sci. U.S.A. 114: 11908-11913.

PMID: # 29146910  2017. Nat Commun. 8: 1547.

PMID: # 28082109  Hartman, JH.|Miller, GP.|Caro, AA.|Byrum, SD.|Orr, LM.|Mackintosh, SG.|Tackett, AJ.|MacMillan-Crow, LA.|Hallberg, LM.|Ameredes, BT.|Boysen, G.| et al. 2017. Toxicology. 378: 114-124.

PMID: # 28060746  2017. Oncotarget. 8: 11841-11854.

PMID: # 28213406  2017. Am. J. Physiol. Heart Circ. Physiol. 312: H1096-H1104.

PMID: # 28894570  2017. Biomed Rep. 7: 226-230.

Citations 1 to 10 of 20 total
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Rated 5 out of 5 by from Good features! I used antimycin A for OxPhos inhibition in oral epithelial cells. It worked well, and showed similar results as other inhibitors of the same pathway I used.
Date published: 2019-07-08
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