Aniline has been reported to be toxic to the spleen via iron overload and induction of oxidative stress via Heme Oxygenase 1 up-regulation. Toxicity of this agent on the spleen is characterized by hyperplasia, fibrosis, and vascular congestion in rats. Studies suggest that this compound causes significant increase in both p-IKKα and p-IKKβ which in-turn increases NF-κB and AP-1 binding activity. In other experiments, Aniline displays a capacity to induce methemoglobinemia, glutathione depletion, membrane cytoskeletal changes, loss of circulating blood cells, and adversely affects blood stability.
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See how others have used Aniline. Click on the entry to view the PubMed entry .
PMID: # 19251893 Shin, KA. et al. 2009. Appl. Environ. Microbiol. 75: 2694-2704.
PMID: # 18793663 Ma, H. et al. 2008. Toxicol. Appl. Pharmacol. 233: 247-253.
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