AnilineCAS: 62-53-3
MF: C6H7N
MW: 93.13
An oxidative stress, NF-κB and AP-1 inducer that has toxic effects on the spleen.

Aniline (CAS 62-53-3)

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Synonym: Phenylamine; Aminobenzene
Application: An oxidative stress, NF-κB and AP-1 inducer that has toxic effects on the spleen
CAS Number: 62-53-3
Purity: ≥99%
Molecular Weight: 93.13
Molecular Formula: C6H7N
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Aniline has been reported to be toxic to the spleen via iron overload and induction of oxidative stress via Heme Oxygenase 1 up-regulation. Toxicity of this agent on the spleen is characterized by hyperplasia, fibrosis, and vascular congestion in rats. Studies suggest that this compound causes significant increase in both p-IKKα and p-IKKβ which in-turn increases NF-κB and AP-1 binding activity. In other experiments, Aniline displays a capacity to induce methemoglobinemia, glutathione depletion, membrane cytoskeletal changes, loss of circulating blood cells, and adversely affects blood stability.


References

1. Singh, H., et al. 2007. Arh Hig Rada Toksikol. 58: 275-285. PMID: 17913681
2. Wang, J., et al. 2008. Toxicol. Appl. Pharmacol. 230: 227-234. PMID: 18420242
3. Wang, J., et al. 2010. Free Radic. Biol. Med. 48: 513-518. PMID: 19969074

Physical State :
Liquid
Solubility :
Soluble in water (36 mg/ml at 20° C), acetone, and ethanol.
Storage :
Store at room temperature
Melting Point :
-6° C (lit.)
Boiling Point :
184° C (lit.)
Density :
1.02 g/mL at 25° C (lit.)
Refractive Index :
n20D 1.59 (lit.)
pK Values :
pKb: 4.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
BW6650000
PubChem CID :
6115
Merck Index :
14: 659
MDL Number :
MFCD00007629
EC Number :
200-539-3
Beilstein Registry :
605631
SMILES :
C1=CC=C(C=C1)N

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Aniline  Product Citations

See how others have used Aniline. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 19251893  Shin, KA. et al. 2009. Appl. Environ. Microbiol. 75: 2694-2704.

PMID: # 18793663  Ma, H. et al. 2008. Toxicol. Appl. Pharmacol. 233: 247-253.

Citations 1 to 2 of 2 total
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