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Angiotensin II, Human (CAS 4474-91-3)

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Synonym: Ang II

Application: A peptide involved in the regulation of blood pressure

CAS Number: 4474-91-3

Purity: ≥93%

Molecular Weight: 1046.18

Molecular Formula: C₅₀H₇₁N₁₃O₁₂

* Refer to Certificate of Analysis for lot specific data (including water content).

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Angiotensin II plays an important role in the regulation of blood pressure and has strong vasoconstrictive effects. It also stimulates the release of aldosterone from the adrenal gland and inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II increases the entry of Ca²⁺ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase (MYLK). It also elicits an increase in voltage-dependent delayed rectifier K⁺ current in neurons and activates JAK2 in smooth muscle cells. Furthermore, angiotensin II activates FAK (p125FAK) and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. It also activates c-Src (p60c-src), ERK1/2, JNK, and p38α (p38 MAP Kinase) in vascular smooth muscle cells.

Physical State :

solid

Sequence :

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

Solubility :

Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).

Storage :

Store at -20° C

Density :

1.43 g/cm³

Refractive Index :

n²⁰_D 1.66

IC50 :

Type-1B angiotensin II receptor: IC₅₀ = 0.4 nM (rat); Type-1A angiotensin II receptor: IC₅₀ = 0.4 nM (rat); AT-1: IC₅₀ = 1.5 nM (rat); Angiotensin II receptor: IC₅₀ = 4 nM (human)

Ki Data :

AT-1: K_i= 0.1 nM (rat); AT-2: K_i= 0.2 nM (human); Type-1B angiotensin II receptor: K_i= 0.31 nM (rat); Type-1 angiotensin II receptor: K_i= 0.9 nM (human)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

BW2165000

PubChem CID :

172198

Merck Index :

14: 651

MDL Number :

MFCD00133092

Beilstein Registry :

4289487

SMILES :

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N

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Angiotensin II, Human Product Citations

See how others have used Angiotensin II, Human. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

Citations 1 to 1 of 1 total

Rated 5 out of 5 by KG from Murata et al Murata et al. (PubMed ID 26341998) found that the vasopressor hormone, angiotensin II, accelerated mammary gland development in hypertensive pregnant mice. -SCBT Publication Review

Date published: 2015-01-26

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Angiotensin II, Human (CAS 4474-91-3)

QUICK LINKS

Download SDS (MSDS)

Certificate of Analysis

Angiotensin II, Human Product Citations

Angiotensin II, Human (CAS 4474-91-3)

QUICK LINKS

Download SDS (MSDS)

Certificate of Analysis

Angiotensin II, Human Product Citations

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