Angiotensin II, HumanA peptide involved in the regulation of blood pressure

Angiotensin II, Human (CAS 4474-91-3)

Angiotensin II, Human | CAS 4474-91-3 is rated 5.0 out of 5 by 1.
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Synonym: Ang II
Application: A peptide involved in the regulation of blood pressure
CAS Number: 4474-91-3
Purity: ≥93%
Molecular Weight: 1046.18
Molecular Formula: C50H71N13O12
* Refer to Certificate of Analysis for lot specific data (including water content).
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Angiotensin II plays an important role in the regulation of blood pressure and has strong vasoconstrictive effects. It also stimulates the release of aldosterone from the adrenal gland and inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase (MYLK). It also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons and activates JAK2 in smooth muscle cells. Furthermore, angiotensin II activates FAK (p125FAK) and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. It also activates c-Src (p60c-src), ERK1/2, JNK, and p38α (p38 MAP Kinase) in vascular smooth muscle cells.

Physical State :
solid
Sequence :
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Solubility :
Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).
Storage :
Store at -20° C
Density :
1.43 g/cm3
Refractive Index :
n20D 1.66
IC50 :
Type-1B angiotensin II receptor: IC50 = 0.4 nM (rat); Type-1A angiotensin II receptor: IC50 = 0.4 nM (rat); AT-1: IC50 = 1.5 nM (rat); Angiotensin II receptor: IC50 = 4 nM (human)
Ki Data :
AT-1: Ki= 0.1 nM (rat); AT-2: Ki= 0.2 nM (human); Type-1B angiotensin II receptor: Ki= 0.31 nM (rat); Type-1 angiotensin II receptor: Ki= 0.9 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
BW2165000
PubChem CID :
172198
Merck Index :
14: 651
MDL Number :
MFCD00133092
Beilstein Registry :
4289487
SMILES :
CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N

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Angiotensin II, Human  Product Citations

See how others have used Angiotensin II, Human. Click on the entry to view the PubMed entry .

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PMID: # 30677512  Li, S.|Zhu, Z.|Xue, M.|Yi, X.|Liang, J.|Niu, C.|Chen, G.|Shen, Y.|Zhang, H.|Zheng, J.|Zhao, C.|Liang, Y.|Cong, W.|Wang, Y.|Jin, L.| et al. 2019. Biochim Biophys Acta Mol Basis Dis.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Murata et al Murata et al. (PubMed ID 26341998) found that the vasopressor hormone, angiotensin II, accelerated mammary gland development in hypertensive pregnant mice. -SCBT Publication Review
Date published: 2015-01-26
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