Andrographolide is a bicyclic diterpenoid lactone displaying antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties. This chemical is an irreversible antagonist of NF-κB and prevents in vitro T cell activation. Andrographolide displays no effect on IκBa degradation but downregulates iNOS and Mac-1 expressions and ROS production. It has been shown to prevent endotoxin shock in mouse models and is reported to activate PI 3K/Akt pathways. Andrographolide is also an inhibitor of ERK.
1. Yu, Bu-Chin., et al., 2003. Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta medica. 69(12): 1075-9. PMID: 14750020
2. Chen, Jiun-Han., et al., 2004. Andrographolide suppresses endothelial cell apoptosis via activation of phosphatidyl inositol-3-kinase/Akt pathway. Biochemical pharmacology. 67(7): 1337-45. PMID: 15013849
3. Xia, Yi-Feng., et al., 2004. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. Journal of immunology (Baltimore, Md. : 1950). 173(6): 4207-17. PMID: 15356172
See how others have used Andrographolide. Click on the entry to view the PubMed entry .
PMID: # 28097636 Banerjee, M.|Parai, D.|Chattopadhyay, S.|Mukherjee, SK.| et al. 2017. Folia Microbiol. (Praha). 62: 237-244.
PMID: # 27084510 Banerjee, M. et al. 2016. Journal of biomedical science. 23: 40.
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