Anastrozole-d12 CAS: 120511-73-1 (unlabeled)
MF: C17H7D12N5
MW: 305.44
A deuterium labeled CYP19 (aromatase) inhibitor.

Anastrozole-d12 (CAS 120511-73-1 (unlabeled))

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Alternate Names: Anastrol-d12; Arimidex-d12
Application: Anastrozole-d12 is a deuterium labeled CYP19 (aromatase) inhibitor
CAS Number: 120511-73-1 (unlabeled)
Molecular Weight: 305.44
Molecular Formula: C17H7D12N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Anastrozole-d12 is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition.


References

Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)

Physical State :
Solid
Solubility :
Soluble in Ethyl Acetate
Storage :
Store at -20° C
Melting Point :
83-85° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
[2H]C([2H])([2H])C(C#N)(C1=CC(=CC(CN2C=NC=N2)=C1)C(C#N)(C([2H])([2H])[2H])C([2H])([2H])[2H])C([2H])([2H])[2H]

Download SDS (MSDS)

Certificate of Analysis

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Anastrozole-d12 (CAS 120511-73-1 (unlabeled))  Product Citations

See how others have used Anastrozole-d12 (CAS 120511-73-1 (unlabeled)). Click on the entry to view the PubMed entry .

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PMID: # 30464397  Drug Des Devel Ther. 3653-3664.

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