AnandamideAn endogenous cannabinoid receptor ligand

Anandamide (CAS 94421-68-8)

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Synonym: AEA; N-Arachidonoylethanolamine; (all-Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide
Application: An endogenous cannabinoid receptor ligand
CAS Number: 94421-68-8
Molecular Weight: 347.53
Molecular Formula: C22H37NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Anandamide is an endogenous cannabinoid (CB) ligand that binds to brain and peripheral cannabinoid receptors (CB1: Ki=52nm; CB2: Ki=1930nm) and VR1 (Ki=5.78μM), inhibits the binding of [3H]HU-243 to synaptosomal membranes (Ki=52 nM), and inhibits NF-κB activation through direct binding to IKK&beta. Some other reported effects of Anandamide are: production of hypothermia and analgesia in mice, decrease in spontaneous motor activity, activation of the MAP kinase (MAPK/ERK) signalling pathway, induction of apoptosis independently of cannabinoid or vanilloid receptors, and inhibition of human breast cancer cell proliferation and migration of tumor cells and T lymphocytes.

Additional forms available:
sc-200790 (dissolved in solvent) Anandamide is an activator of GPR55.

Appearance :
Physical State :
Solubility :
Soluble in DMSO (~30 mg/ml), DMF (~10 mg/ml), anhydrous ethanol (5 mg/ml), PBS, pH 7.2 (~100 mg/ml), and water (<0.1 mg/ml at 25 °C).
Storage :
Store at -80° C
Density :
0.92 g/mL at 25° C (lit.)
Refractive Index :
n20D 1.50 (Predicted)
IC50 :
Cannabinoid CB1 receptor: IC50 = 39 nM (mouse); Cannabinoid CB1 receptor: IC50 = 40 nM (rat); Inhibition of the twitch response in mouse vas deferens: IC50 = 52 nM; FAAH: IC50 = 3.4 µM (human); Anandamide amidohydrolase: IC50 = 11.75 µM (rat)
Ki Data :
CB1: Ki= 11 nM (human); Cannabinoid CB1 receptor: Ki= 22 nM (rat); Cannabinoid receptor: Ki= 25 nM (rat); Cannabinoid receptor: Ki= 52 nM (mouse); Cannabinoid CB1 receptor: Ki= 89 nM (mouse)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 624
MDL Number :
Beilstein Registry :

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Certificate of Analysis

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Anandamide  Product Citations

See how others have used Anandamide. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23315130  Pai, WY. et al. 2013. Transgenic Res. 22: 823-38.

Citations 1 to 1 of 1 total
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