AnandamideAn endogenous cannabinoid receptor ligand

Anandamide (CAS 94421-68-8)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 63ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: AEA; N-Arachidonoylethanolamine; (all-Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide
Application: An endogenous cannabinoid receptor ligand
CAS Number: 94421-68-8
Molecular Weight: 347.53
Molecular Formula: C22H37NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Anandamide is an endogenous cannabinoid (CB) ligand that binds to brain and peripheral cannabinoid receptors (CB1: Ki=52nm; CB2: Ki=1930nm) and VR1 (Ki=5.78μM), inhibits the binding of [3H]HU-243 to synaptosomal membranes (Ki=52 nM), and inhibits NF-κB activation through direct binding to IKK&beta. Some other reported effects of Anandamide are: production of hypothermia and analgesia in mice, decrease in spontaneous motor activity, activation of the MAP kinase (MAPK/ERK) signalling pathway, induction of apoptosis independently of cannabinoid or vanilloid receptors, and inhibition of human breast cancer cell proliferation and migration of tumor cells and T lymphocytes.

Additional forms available:
sc-200790 (dissolved in solvent) Anandamide is an activator of GPR55.

Appearance :
Viscous
Physical State :
Liquid
Solubility :
Soluble in DMSO (~30 mg/ml), DMF (~10 mg/ml), anhydrous ethanol (5 mg/ml), PBS, pH 7.2 (~100 mg/ml), and water (<0.1 mg/ml at 25 °C).
Storage :
Store at -80° C
Density :
0.92 g/mL at 25° C (lit.)
Refractive Index :
n20D 1.50 (Predicted)
IC50 :
Cannabinoid CB1 receptor: IC50 = 39 nM (mouse); Cannabinoid CB1 receptor: IC50 = 40 nM (rat); Inhibition of the twitch response in mouse vas deferens: IC50 = 52 nM; FAAH: IC50 = 3.4 µM (human); Anandamide amidohydrolase: IC50 = 11.75 µM (rat)
Ki Data :
CB1: Ki= 11 nM (human); Cannabinoid CB1 receptor: Ki= 22 nM (rat); Cannabinoid receptor: Ki= 25 nM (rat); Cannabinoid receptor: Ki= 52 nM (mouse); Cannabinoid CB1 receptor: Ki= 89 nM (mouse)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
JX3842500
PubChem CID :
5281969
Merck Index :
14: 624
MDL Number :
MFCD00153766
Beilstein Registry :
7079463
SMILES :
CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)NCCO

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Anandamide  Product Citations

See how others have used Anandamide. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23315130  Pai, WY. et al. 2013. Transgenic Res. 22: 823-38.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 56ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 118ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.