Amthamine CAS: 142437-67-0
MF: C6H11N3S
MW: 157.23
A very selective agonist of the histamine H2-receptor.

Amthamine (CAS 142437-67-0)

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Application: Amthamine is a very selective agonist of the histamine H2-receptor
CAS Number: 142437-67-0
Molecular Weight: 157.23
Molecular Formula: C6H11N3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Amthamine is a highly selective histamine H2 receptor agonist, devoid of stimulatory activity at H1 and H3 receptors. Being very similar to histamine, its mechanism of action is to inhibit receptor -mediated eosinophil peroxidase. It induces a dose-dependent increase in gastric acid secretion and is a superior alternative to other H2 agonists for the study of gastric acid secretion. Amthamine has been shown to suppress the release of serotonin and has been used to study the involvement of H1 and H2 receptors on ion secretion.


References

1. Eriks, J.C., et al. 1992. J. Med. Chem. 35: 3239-3246. PMID: 1507209
2. Poli, E., et al. 1993. Agents Actions. 40: 44-49. PMID: 8147269
3. Coruzzi, G., et al. 1993. Naunyn Schmiedebergs Arch. Pharmacol. 348: 77-81. PMID: 8377843
4. Ezeamuzie, C.I., et al. 2000. Br. J. Pharmacol. 131: 482-488. PMID: 11015298
5. Schultheiss, G., et al. 2006. Eur. J. Pharmacol. 546: 161-170. PMID: 16919622
6. Threlfell, S., et al. 2008. J. Neurochem. 107: 745-755. PMID: 18761715

Physical State :
Solid
Solubility :
Soluble in water
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
126688
SMILES :
CC1=C(SC(=N1)N)CCN

Download SDS (MSDS)

Certificate of Analysis

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