AmlodipineAn L-type calcium channel protein inhibitor and blocker

Amlodipine (CAS 88150-42-9)

Amlodipine | CAS 88150-42-9 is rated 5.0 out of 5 by 1.
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Application: An L-type calcium channel protein inhibitor and blocker
CAS Number: 88150-42-9
Purity: >98%
Molecular Weight: 408.88
Molecular Formula: C20H25ClN2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amlodipine is a long-acting dihydropyridine, L-type, calcium channel protein inhibitor and blocker. Amlodipine belongs to a class of cardiovascular drugs, which act at the voltage gated calcium channel of the CaV1, or L-type, class. Amlodipine has been shown to have antihypertensive and antianginal effects. Its activity resides mainly in the (-)-isomer. Amlodipine inhibits growth of human epidermoid carcinoma A431 cells.


References

1. Ueda, S., et al. 1993. Br. J. Clin. Pharmacol. 36: 561-566. PMID: 12959273
2. Mason, R.P., et al. 2003. Arterioscler Thromb. Vasc. Biol. 23: 2155-2163. PMID: 14512371
3. Asano, Y., et al. 2003. Biochem. Biophys. Res. Commun. 311: 625-628. PMID: 14623316
4. Yoshida, J., et al. 2003. Eur. J. Pharmacol. 472: 23-31. PMID: 12860469
5. Yu, T., et al. 2003. Hypertension. 42: 329-334. PMID: 12900427
6. Zhou, M.S., et al. 2004. Am. J. Hypertens. 17: 167-171. PMID: 14751660

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/mL), ethanol (25 mg/mL), water (75.3 mg/mL), DMF (25 mg/mL), acetone, chloroform, ethyl acetate, and methanol.
Storage :
Store at room temperature
Melting Point :
134-136° C
Boiling Point :
~527.2° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
Rattus norvegicus: IC50 = 2.5 nM (Rattus norvegicus); Oryctolagus cuniculus: IC50 = 3 nM (Oryctolagus cuniculus)
Ki Data :
Voltage-gated L-type calcium channel alpha-1C subunit: Ki= 2 nM (Rattus norvegicus); Alpha-2a adrenergic receptor: Ki= 226 nM (human)
pK Values :
pKb: 8.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
US7968329
PubChem CID :
2162
Merck Index :
14: 491
MDL Number :
MFCD00887594
SMILES :
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN

Download SDS (MSDS)

Certificate of Analysis

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Amlodipine  Product Citations

See how others have used Amlodipine. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 23652407  Tamraz, B. et al. 2013. Pharmacogenet. Genomics. 23: 355-64.

PMID: # 27127388  Grossini, E. et al. J Pharmacol Pharmacother. 7: 6-14.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Chen Chen, X. et al. (PubMed 24244746) reported that Amlodipine reduces AngII-induced aortic aneurysms and atherosclerosis in hypercholesterolemic mice. -SCBT Publication Review
Date published: 2015-03-13
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