AmlexanoxAn inhibitor of mast cell release of allergic mediators

Amlexanox (CAS 68302-57-8)

Amlexanox | CAS 68302-57-8 is rated 5.0 out of 5 by 1.
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Synonym: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid Amoxanox AA-673 CHX-3673 Aphthasol Elics Solfa
Application: An inhibitor of mast cell release of allergic mediators
CAS Number: 68302-57-8
Purity: ≥99%
Molecular Weight: 298.29
Molecular Formula: C16H14N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amlexanox inhibits mast cell release of allergic mediators. Amlexanox is also an antiallergic and an antiasthmatic.


References

Rankov, G., et al.: Ophthalmic Res., 22, 359 (1990) Greer, R.O., et al.: J. Oral Mxillofac. Surg., 51, 243 (1993)

Physical State :
Solid
Solubility :
Soluble in ethanol (0.58 mg/ml), DMSO (10 mg/ml), methanol (sparingly), DMF (14 mg/ml), and 1: 1 DMSO: PBS(pH 7.2) (0.5 mg/ml).
Storage :
Store at 4° C
Melting Point :
>300° C (dec.)
Boiling Point :
570° C at 760 mmHg
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
pK Values :
pKa: 3.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DJ3102000
PubChem CID :
2161
Merck Index :
12: 515
MDL Number :
MFCD00864790
Beilstein Registry :
556384
SMILES :
CC(C)C1=CC2=C(C=C1)OC3=NC(=C(C=C3C2=O)C(=O)O)N

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-217630, is provided as an off-white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-12

At what temperature should Amlexanox be stored once resuspended in DMSO and how fast does it degrade?

Asked by: MariaD
Thank you for your question. We highly recommend to make a fresh solution prior to use in your experiments for quality purposes. The storage temperature for sc-217630 is at 4° C. We do not have any information about the rate of degradation.
Answered by: Technical Support
Date published: 2017-01-07

Can you tell me the storage tempeturate of 1mM and 30 mM sc-217630 in DMSO?

Asked by: two2igm05
We highly recommend our customers to make fresh solution prior to their experiments for quality purposes. The storage temperature for sc-217630 is at 4° C.
Answered by: Tech Service 4
Date published: 2016-12-16
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Rated 5 out of 5 by from Zhang et al Zhang et al. (PubMed ID 263384770 found that Amlexanox inhibited prevented ovariectomy-induced bones loss and inhibited osteoclast formation and reabsorption by suppressing RANKL-induced activation of NF-kB. -SCBT Publication Review
Date published: 2015-05-31
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