Aminopterin CAS: 54-62-6
MF: C19H20N8O5
MW: 440.40
A dihydrofolate reductase inhibitor and folic acid antagonist.

Aminopterin (CAS 54-62-6)

Aminopterin | CAS 54-62-6 is rated 5.0 out of 5 by 1.
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Alternate Names: 4-Aminopteroylglutamic acid; 4-Aminofolic acid; 4-Amino-PGA
Application: Aminopterin is a dihydrofolate reductase inhibitor and folic acid antagonist
CAS Number: 54-62-6
Purity: ≥98%
Molecular Weight: 440.40
Molecular Formula: C19H20N8O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Aminopterin is a folic acid antagonist. Potent DHFR (dihydrofolate reductase) inhibitor.

Physical State :
Solid
Solubility :
Soluble in water (partly), 0.1N NaOH, DMSO, NH4OH 2M (49.00 - 51.00 mg/ml), and ethanol (slightly).
Storage :
Store at room temperature
Melting Point :
225° C
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
pK Values :
pKa: 3.47 (Predicted), pKb: 5.46 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MA1050000
PubChem CID :
Merck Index :
14: 472
MDL Number :
MFCD00036692
EC Number :
200-209-9
Beilstein Registry :
69045
SMILES :
C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N

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Certificate of Analysis

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Aminopterin (CAS 54-62-6)  Product Citations

See how others have used Aminopterin (CAS 54-62-6). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27343244  Calise, SJ. et al. 2016. J. Cell. Sci. 129: 3042-52.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Mongkol et al Mongkol et al. (PubMed ID 26352934) found that aminopterin significantly reduced carboxypeptidase B activity in the Anopheline mosquito midgut, which is key for adequate sexual development of plasmodium in the mosquito. -SCBT Publication Review
Date published: 2015-05-18
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