Aminopotentidine CAS: 140873-26-3
MF: C26H35N7O2
MW: 477.6
A histamine H2-receptor antagonist.

Aminopotentidine (CAS 140873-26-3)

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Synonym: 4-Amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]imino]methyl]amino]ethyl]benzamide
Application: A histamine H2-receptor antagonist
CAS Number: 140873-26-3
Molecular Weight: 477.6
Molecular Formula: C26H35N7O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Aminopotentidine is a very potent and specific histamine H2-receptor antagonist with a documented high affinity Kd = 0.3 nM and respective KB values of 220 and 280 nM at human and guinea-pig H2-receptors.


References

1. Ruat, M., et al. 1990. Proc. Natl. Acad. Sci. U.S.A. 87: 1658-1662. PMID: 2308927
2. Hirschfeld, J., et al. 1992. J. Med. Chem. 35: 2231-2238. PMID: 1613748
3. Xie, S.X., et al. 2006. Bioorg. Med. Chem. Lett. 16: 3886-3890. PMID: 16730977

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), and DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
310.52° C (Predicted)
Boiling Point :
709.62° C (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Plasmodium falciparum 3D7: IC50 = 14.7 µM
pK Values :
pKb: 8.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
164435
MDL Number :
MFCD09971018
SMILES :
C1CCN(CC1)CC2=CC(=CC=C2)OCCCN=C(NCCNC(=O)C3=CC=C(C=C3)N)NC#N

Download SDS (MSDS)

Certificate of Analysis

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