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Amidepsine D is an inhibitor of diacylglycerol acyltransferase (DGAT). Amidepsine D shows inhibitory effects in rat liver microsomes (IC50=17.5μM) and Raji cells (IC50=2.8μM). Excessive accumulation of triacetylglycerol is produced by DGAT which may cause fatty liver, obesity and hypertriglyceridemia, and may lead to atherosclerosis, diabetes and metabolic disorders.
H. Tomoda, et al.; J. Antibiot. 48, 937 (1995). Tomoda, et al.; J. Antibiot. 48, 942 (1995).
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