AMI-1, sodium salt CAS: 20324-87-2
MF: C21H12N2O9S2•4Na
MW: 592.42
A PRMT and HIV-1 RT polymerase inhibitor.

AMI-1, sodium salt (CAS 20324-87-2)

AMI-1, sodium salt | CAS 20324-87-2 is rated 5.0 out of 5 by 1.
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Alternate Names: Arginine N-Methyltransferase Inhibitor-1
Application: AMI-1, sodium salt is a PRMT and HIV-1 RT polymerase inhibitor
CAS Number: 20324-87-2
Purity: ≥98%
Molecular Weight: 592.42
Molecular Formula: C21H12N2O9S24Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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AMI-1 is a potent, cell-permeable compound which inhibits protein arginine N-methyltransferases (PRMTs), including human PRMT1 (IC50 = 8.8μM) and yeast-Hmt1p (IC50 = 3.0μM), by blocking peptide-substrate binding. AMI-1 does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site and exhibits minimal effects on both SET (Sub39H1, Suv39H2, SET7) and non-SET (DOT1) lysine N-methyltransferases. AMI-1 suppresses the transcriptional coactivator activity of PRMT1 and PRMT4 and it inhibits HIV-1 RT polymerase (IC50 = 5.0μM). PRMT1 methylates histone H4, and is essential for other subsequent histone modifications.


References

1. Skillman, A Geoffrey., et al., 2002. A novel mechanism for inhibition of HIV-1 reverse transcriptase. Bioorganic chemistry. 30(6): 443-58. PMID: 12642128
2. Cheng, Donghang., et al., 2004. Small molecule regulators of protein arginine methyltransferases. The Journal of biological chemistry. 279(23): 23892-9. PMID: 15056663

Physical State :
Solid
Solubility :
Soluble in water, 100% ethanol, and DMSO.
Storage :
Store at -20° C
IC50 :
Hmt1p: IC50 = 3.0 µM (yest); PRMT: IC50 = 8.8 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1=CC2=C(C=C(C=C2C=C1NC(=O)NC3=CC4=CC(=CC(=C4C=C3)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])[O-].[Na+].[Na+].[Na+].[Na+]

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Certificate of Analysis

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AMI-1, sodium salt (CAS 20324-87-2)  Product Citations

See how others have used AMI-1, sodium salt (CAS 20324-87-2). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26657730  Yuniati, L. et al. 2016. Oncotarget. 7: 3128-43.

PMID: # 25274782  Tibshirani, M. et al. 2015. Hum. Mol. Genet. 24: 773-86.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Cheng et al Cheng et al. (PubMed ID 15056663) found that AMI-1, sodium salt blocked arginine methylation of cellular proteins and regulated estrogen and androgen receptor response by inhibiting arginine methyltransferase activity. -SCBT Publication Review
Date published: 2015-04-30
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