AM3102An endogenous agonist for proliferator-activated receptor α

AM3102 (CAS 213182-22-0)

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Synonym: KDS-5104; N-[(1R)-2-hydroxy-1-methylethyl-9Z- octadecenamide
Application: An endogenous agonist for proliferator-activated receptor α
CAS Number: 213182-22-0
Molecular Weight: 339.60
Molecular Formula: C21H41NO2
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AM3102 is an endogenous agonist for proliferator-activated receptor α (PPARα). The biological effects of OEA are terminated by N-acylethanolamine-hydrolyzing acid amidase and fatty-acid amide hydrolase. AM3102 is an OEA analog that stimulates PPARα transcriptional activity with an EC50 value of 100 nM. It is resistant to enzymatic hydrolysis and enhances transcriptional activity of PPARα. AM3102 demonstrates weak affinity for the peripheral cannabinoid (CB2) and central cannabinoid (CB1) receptors with Ki values of 26 and 33 µM, respectively.


References

1 Astarita, G., et al. 2006. J Pharmacol Exp Ther. 318: 563-570. PMID: 16702440
2 Wang, J. and Ueda, N. 2008. Curr Opin Nephrol Hypertens. 17: 1-10. PMID: 18090663
3 Lin, S., et al. 1998. J Med Chem .41: 5353-5361. PMID: 9876105

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
OC[C@@H] (C) NC(CCCCCCC/C=C\CCCCCCCC) =O

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