AM 80

AM 80 (CAS 94497-51-5)

AM 80 | CAS 94497-51-5 is rated 5.0 out of 5 by 1.
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Synonym: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tet ramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid; Tamibarotene
Application: A RARα agonist that induces differentiation and apoptosis
CAS Number: 94497-51-5
Purity: >99%
Molecular Weight: 351.44
Molecular Formula: C22H25NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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AM 80 is a RARα (retinoic acid receptor α) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. AM 80 displays anticancer activity against acute promyelocytic leukemia in vitro and exhibits antiproliferative effects against a variety of tumor cell lines. AM 80 is an activator of RAR β.


References

1. Kagechika, H., et al. 1988. J. Med. Chem. 31: 2182-2192. PMID: 3184125
2. Jimi, K., et al. 2007. Int. J. Oncol. 31: 397-404. PMID: 17611697
3. Takenaga, Y., et al. 2009. Biol. Pharm. Bull. 32: 225-231. PMID: 1918238
Jin, Y. et al. 2014. Int. Immunopharmacol. 23(2): 537-545. PMID: 25448496

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in 1.1eq. NaOH (100 mM), DMSO (50 mM), methanol, and water (slightly).
Storage :
Store at room temperature
Melting Point :
228-230° C
Boiling Point :
449.6° C at 760 mmHg
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
RARα : IC50 = 78 nM (human); NB4: IC50 = 4.81 µM (human); HL-60: IC50 = 6 µM (human); MOLT-4: IC50 = 19.5 µM (human); U-937: IC50 = 20.2 µM (human)
Ki Data :
RARα : Ki= 6.5 nM (human); RARβ: Ki= 30 nM
pK Values :
pKa: 3.83 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DH6940000
PubChem CID :
108143
Merck Index :
14: 9047
MDL Number :
MFCD00866188
Beilstein Registry :
3564473
SMILES :
CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Jin Jin, Y. et al. (PubMed 25448496) reported that AM 80 (Tamibarotene) modulated the local immune response in experimental periodontitis. -SCBT Publication Review
Date published: 2015-03-02
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