AM 1172 is a potent and selective inhibitor of anandamide uptake, resistant to FAAH (fatty acid amide hydrolase) hydrolysis. Metabolically stable "reversed" isomer of AM 404 (sc-200363). AM 1172 is an inhibitor of FAAH. AM 1172 is an activator of CB1 and CB2.
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172: D. Fegley, et al.; PNAS 101, 8756 (2004)
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Solution in ethanol
Soluble in water (0.15 mg/ml at 20° C), ethanol, DMSO (~30 mg/ml), DMF (~30 mg/ml), and PBS pH 7.2 (~0.15 mg/ml).
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