Altenusin CAS: 31186-12-6
MF: C15H14O6
MW: 290.3
An antifungal penicillide and strong pp60c-Src inhibitor.

Altenusin (CAS 31186-12-6)

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Alternate Names: MS 341
Application: Altenusin is an antifungal penicillide and strong pp60c-Src inhibitor
CAS Number: 31186-12-6
Purity: ≥97%
Molecular Weight: 290.3
Molecular Formula: C15H14O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Altenusin is an antifungal penicillide. Non-competitive, specific N-SMase (neutral sphingomyelinase) and strong c-Src (pp60c-Src) inhibitor. Inhibits c-Fms-CSF-1R (cFMS receptor tyrosine kinase) which is implicated in cancer and bone diseases. MYLK (Myosin light chain kinase) inhibitor. Exhibits anti-HIV-1 integrase activity.


References

1. Rosett, T., et al. 1957. Biochem. J. 67: 390-400. PMID: 13479395
2. Thomas, R., 1961. Biochem. J. 80: 234-240. PMID: 13776530
3. Nakanishi, S., et al. 1995. Biosci. Biotechnol. Biochem. 59: 1333-1335. PMID: 7670197
4. Uchida, R., et al. 1999. J. Antibiot. 52: 572-574. PMID: 10470682
5. Singh, S.B., et al. 2003. J. Ind. Microbiol. Biotechnol. 30: 721-731. PMID: 14714192
6. Dayam, R., et al. 2006. Med. Res. Rev. 26: 271-309. PMID: 16496343

Physical State :
Solid
Solubility :
Soluble in DMSO, and 100% ethanol.
Storage :
Store at -20° C
Melting Point :
195.52° C (Predicted)
Boiling Point :
~525.1° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD14635401
SMILES :
CC1=CC(=C(C=C1C2=C(C=CC(=C2)OC)C(=O)OO)O)O

Download SDS (MSDS)

Certificate of Analysis

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