alpha-ZearalenolAn estrogenic synthetic derivative of the Zeralenone mycotoxin

α-Zearalenol (CAS 36455-72-8)

α-Zearalenol | CAS 36455-72-8 is rated 4.0 out of 5 by 1.
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Application: An estrogenic synthetic derivative of the Zeralenone mycotoxin
CAS Number: 36455-72-8
Purity: >99%
Molecular Weight: 320.3
Molecular Formula: C18H24O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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α-Zearalenol is a synthetic derivative of the macrolactone mycotoxin zearalenone (sc-204943) isolated from the Fusarium roseum fungus. α-Zearalenol is estrogenically active and demonstrates induction of premature uterine growth, increase of nuclear estrogen receptor levels, and a five fold increase of ornithine decarboxylase level (ODC). The increase of ODC level was 20-fold more pronounced with α-zearalenol than zearalenone, and α-Zearalenol demonstrated three times more potent estrogenic activity than zearalenone.


References

1. Hagler, W.M., et al. 1979. Appl. Environ. Microbiol. 37: 849-853. PMID: 485136
2. Mirocha, C.J., et al. 1979. Appl. Environ. Microbiol. 38: 749-750. PMID: 161492
3. Powell-Jones, W., et al. 1981. Mol. Pharmacol. 20: 35-42. PMID: 6457245
4. Sheehan, D.M., et al. 1984. Teratology. 29: 383-392. PMID: 6235618
5. Luongo, D., et al. 2008. Toxicon. 52: 156-162. PMID: 18620720

Physical State :
Solid
Derived From :
Fusarium
Solubility :
Soluble in water (partly), ethanol, methanol, DMF, and DMSO.
Storage :
Store at -20° C
Melting Point :
158-166° C
Boiling Point :
598.97° C at 760 mmHg (Predicted)
Density :
1.17 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5284645
MDL Number :
MFCD16657008
SMILES :
C[C@H]1CCC[C@@H](CCC/C=C/C2=CC(=CC(=C2C(=O)O1)O)O)O

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Certificate of Analysis

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alpha-Zearalenol  Product Citations

See how others have used alpha-Zearalenol. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26255852  Nakamura, U. et al. 2015. Theriogenology. 84: 1342-9.

Citations 1 to 1 of 1 total
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Date published: 2015-04-20
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