α-Estradiol is an endogenous ligand for estrogen receptors ERα (Ki = 0.2 nM) and ERβ (Ki = 1.2 nM). Studies indicate that α-Estradiol is a short acting estrogen which only forms complexes with estrogen ligand receptors for a short period of time. These studies suggest that α-estradiol is beneficial in studying the affects caused by the MAPK signaling cascade such as cell division, neuronal differentiation, and neuronal survival in the developing brain. Furthermore, α-estradiol inhibits the influx of calcium in human aortic smooth muscle cells.
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2. Seeger, H., et al., 1999. Calcium antagonistic effect of 17 alpha-estradiol derivatives: in vitro examinations. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 13(4): 246-8. PMID: 10533159
3. Toran-Allerand, C Dominique., et al., 2002. ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(19): 8391-401. PMID: 12351713
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