Aloe-emodinAn inhibitor against the P-388 leukemia in mice

Aloe-emodin (CAS 481-72-1)

Aloe-emodin | CAS 481-72-1 is rated 5.0 out of 5 by 1.
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Synonym: 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone; 3-Hydroxymethylchrysazine; Rhabarberone
Application: An inhibitor against the P-388 leukemia in mice
CAS Number: 481-72-1
Purity: ≥98%
Molecular Weight: 270.24
Molecular Formula: C15H10O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Aloe-emodin shows significant inhibitory activity against the P-388 leukemia in mice when administered as a suspension in acetone-Tween 80. Has a specific in vitro and in vivo antineuroectodermal tumor activity.


References

Hung, K., et al.: J. Exp. Med., 188, 2357 (1998), Gazzola, P.T., et al.: Cancer Res., 60, 2800 (2000), Irie, T., et al.: Int. J. Cancer, 121, 8784 (2007), Zhao, J., et al.: Eur. J. Neurol., 14, 510 (2007),

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (partly), hot alcohol, methanol, chloroform, and DMSO (50 mg/ml).
Storage :
Store at -20° C
Melting Point :
223-224° C (dec.)
Boiling Point :
~568.8° C at 760 mmHg (Predicted)
Density :
1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.75 (Predicted)
IC50 :
Intestinal alkaline phosphatase: IC50 = 2.88 µM (mouse); Aldehyde dehydrogenase, cytosolic 1: IC50 = 6 µM (rat); HCT-116: IC50 = 8.7 µM (human); HepG2: IC50 = 10 µM (human); SK-OV-3: IC50 = 20 µM (human)
Ki Data :
P2Y12: Ki>10 µM (human)
pK Values :
pKa: 6.3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CB6712200
PubChem CID :
10207
Merck Index :
14: 306
MDL Number :
MFCD00017373
EC Number :
207-571-7
Beilstein Registry :
2059062
SMILES :
OCC1=CC2=C(C(O)=C1)C(=O)C1=C(C=CC=C1O)C2=O

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Certificate of Analysis

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Aloe-emodin  Product Citations

See how others have used Aloe-emodin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27350340  Yang, M. et al. 2016. Biomol Ther (Seoul). 24: 395-401.

PMID: # 24358188  Lee, YS. et al. 2013. PloS one. 8: e82479.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Chena Q; et al Chena Q; et al. (PubMed ID: 26295333) determined that Aloe-emodin effectively inhibited cancer development in MCF-7cells. -SCBT Publication Review
Date published: 2015-02-06
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