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Naturally occurring constituent of cruciferous vegetables that has anti-tumor and anti-oxidant properties. Induces the activity of phase II detoxification enzymes in the urinary bladder and, thus, may be chemoprotective against bladder cancer.
Srivastava, S.K., et al., Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Carcinogenesis 24, 1665-1670, (2003) Manesh, C., and Kuttan, G., Anti-tumour and anti-oxidant activity of naturally occurring isothiocyanates. J. Exp. Clin. Cancer Res 22, 193-199, (2003) Munday, R., and Munday, C.M., Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables. Nutr. Cancer 44, 52-59, (2002) Ippoushi, K., et al., Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages. Life Sci. 71, 411-419, (2002)
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