Allyl isothiocyanateA compound which induces phase II detoxification enzymes in urinary bladder

Allyl isothiocyanate (CAS 57-06-7)

Allyl isothiocyanate | CAS 57-06-7 is rated 5.0 out of 5 by 1.
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Synonym: AITC; Oil of mustard
Application: A compound which induces phase II detoxification enzymes in urinary bladder
CAS Number: 57-06-7
Purity: ≥95%
Molecular Weight: 99.15
Molecular Formula: C4H5NS
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Naturally occurring constituent of cruciferous vegetables that has anti-tumor and anti-oxidant properties. Induces the activity of phase II detoxification enzymes in the urinary bladder and, thus, may be chemoprotective against bladder cancer.


References

Srivastava, S.K., et al., Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Carcinogenesis 24, 1665-1670, (2003) Manesh, C., and Kuttan, G., Anti-tumour and anti-oxidant activity of naturally occurring isothiocyanates. J. Exp. Clin. Cancer Res 22, 193-199, (2003) Munday, R., and Munday, C.M., Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables. Nutr. Cancer 44, 52-59, (2002) Ippoushi, K., et al., Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages. Life Sci. 71, 411-419, (2002)

Physical State :
Liquid
Solubility :
Soluble in water (2 mg/ml at 20° C), ethanol, ether, acetone, and benzene.
Storage :
Store at 4° C
Melting Point :
-80° C (lit.)
Boiling Point :
150° C (lit.)
Density :
1.01 g/mL at 25° C
Refractive Index :
n20D 1.53
IC50 :
ANKTM1: EC5050 = 398 nM (human); Sclerotinia sclerotiorum: EC5050 = 71.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NX8225000
PubChem CID :
5971
Merck Index :
14: 295
MDL Number :
MFCD00004822
EC Number :
200-309-2
Beilstein Registry :
773748
SMILES :
C=CCN=C=S

Download SDS (MSDS)

Certificate of Analysis

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Allyl isothiocyanate  Product Citations

See how others have used Allyl isothiocyanate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27720932  Coavoy-Sánchez, SA. et al. 2016. Pharmacol. Res. 113: 686-694.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Ling X; et al Ling X; et al. (PubMed ID: 26396928) determined that Allyl isothiocyanate enhances the activity of cisplatin in vivo and in vitro. -SCBT Publication Review
Date published: 2015-05-21
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