Allicin, an active compound of garlic, is unstable in aqueous solution without formic acid. It rapidly decomposes mainly to diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS), and ajoene. DATS and DADS act as donors of H2S donors, which plays a cell signaling role similar to NO and CO. Allicin exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Additionally, allicin inhibits telomerase activity and inducible nitric oxide synthase (iNOS; NOS II) expression and promotes apoptosis.
1. Ankri, S., et al., 1997. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrobial agents and chemotherapy. 41(10): 2286-8. PMID: 9333064
2. Dirsch, V M., et al., 1998. Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase. Atherosclerosis. 139(2): 333-9. PMID: 9712340
3. Ankri, S., et al., 1999. Antimicrobial properties of allicin from garlic. Microbes and infection / Institut Pasteur. 1(2): 125-9. PMID: 10594976
4. Elkayam, A., et al., 2001. The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats. American journal of hypertension. 14(4 Pt 1): 377-81. PMID: 11336185
5. Hirsch, K., et al., 2000. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutrition and cancer. 38(2): 245-54. PMID: 11525603
6. Sun, Li., et al., 2003. Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells. World journal of gastroenterology : WJG. 9(9): 1930-4. PMID: 12970878
7. Oommen, Suby., et al., 2004. Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. European journal of pharmacology. 485(1-3): 97-103. PMID: 14757128
8. Cutler, R R., et al., 2004. Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus. British journal of biomedical science. 61(2): 71-4. PMID: 15250668
9. Davis, Stephen R., et al., 2005. An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic. Mycoses. 48(2): 95-100. PMID: 15743425
10. Chung, Lip Yong., et al., 2006. The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. Journal of medicinal food. 9(2): 205-13. PMID: 16822206
11. Gardner, Christopher D., et al., 2007. Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. Archives of internal medicine. 167(4): 346-53. PMID: 17325296
12. Benavides, Gloria A., et al., 2007. Hydrogen sulfide mediates the vasoactivity of garlic. Proceedings of the National Academy of Sciences of the United States of America. 104(46): 17977-82. PMID: 17951430
13. El-Kashef, D.H. et al. 2015. Int. Immunopharmacol. 29(2): 679-686. PMID: 26391062
See how others have used Allicin. Click on the entry to view the PubMed entry .
PMID: # 30537531 Dwivedi, VP.|Bhattacharya, D.|Singh, M.|Bhaskar, A.|Kumar, S.|Fatima, S.|Sobia, P.|Kaer, LV.|Das, G.| et al. 2018. J Ethnopharmacol. 243: 111634.
PMID: # 28693193 Huang, L. et al. 2017. Oncol Lett. 14: 468-474.
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