ALK5 Inhibitor IIAn ATP-competitive inhibitor of TGF-β RI kinase

ALK5 Inhibitor II (CAS 446859-33-2)

ALK5 Inhibitor II | CAS 446859-33-2 is rated 5.0 out of 5 by 1.
  • y_2019, m_12, d_5, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_221234, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 47ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: RepSox; TGF-β RI Kinase Inhibitor II
Application: An ATP-competitive inhibitor of TGF-β RI kinase
CAS Number: 446859-33-2
Purity: ≥97%
Molecular Weight: 287.32
Molecular Formula: C17H13N5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

ALK5 Inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). TGF β RI (ALK5) Inhibitor II affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16μM), minimally.


References

1. Gellibert, F. et al. 2004. J. Med. Chem. 47(18): 4494-4506. PMID: 15317461

2. Ichida, J.K., Blanchard, J., Lam, K., et al. Cell Stem Cell 5(5), 491-503 (2009).

Usage :
A stock solution of can be made by dissolving in organic solvent purged with Inert Gas. Ethanol (2 mg/ml), DMSO, and DMF (20 mg/ml).
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), methanol (5 mg/ml), and ethanol (50 mM).
Storage :
Store at -20° C
Melting Point :
191° C
Boiling Point :
501.91° C at 760 mmHg (Predicted)
Density :
1.30 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
Autophosphorylation of TGF-β RI kinase: IC50 = 4 nM (HepG2 cells); Cellular assay of TGF β RI kinase: IC50 = 18 nM (HepG2 cells); Binding of TGF-β RI kinase: IC50 = 23 nM (HepG2 cells); p38 MAPK: IC50 >16 µM; GSK3: IC50 >16 µM
pK Values :
pKa: 10.05 (Predicted), pKb: 2.82 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
449054
MDL Number :
MFCD09037561
SMILES :
CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

ALK5 Inhibitor II  Product Citations

See how others have used ALK5 Inhibitor II. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 29438662  Tamai, R.|Kiyoura, Y.| et al. 2018. Life Sci. 198: 8-17.

PMID: # 27786288  Yamashita-Sugahara, Y.|Matsumoto, M.|Ohtaka, M.|Nishimura, K.|Nakanishi, M.|Mitani, K.|Okazaki, Y.| et al. 2016. Sci Rep. 6: 35908.

PMID: # 25910951  Choi, SH. et al. 2015. Clinical cancer research : an official journal of the American Association for Cancer Research. 21: 3716-26.

Citations 1 to 3 of 3 total

How is the purity determined?

Asked by: two2igm05
The purity is determined via HPLC.
Answered by: Chemical Support 4
Date published: 2017-02-25

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. ALK5 Inhibitor II, sc-221234, is a yellow powder.
Answered by: TechService7
Date published: 2017-02-14
  • y_2019, m_12, d_5, h_22CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_221234, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 97ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Jajosky Jajosky, AN. et al. (PubMed 24855276) reported that RepSox (ALK5 Inhibitor II) slows decay of CD43+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. -SCBT Publication Review
Date published: 2015-03-30
  • y_2019, m_12, d_5, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_221234, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 3ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.