Alfuzosin hydrochloride CAS: 81403-68-1
MF: C19H27N5O4•HCl
MW: 425.91
An α 1 adrenoceptor antagonist.

Alfuzosin hydrochloride (CAS 81403-68-1)

Alfuzosin hydrochloride | CAS 81403-68-1 is rated 5.0 out of 5 by 1.
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Alternate Names: Uroxatral; Urion; Xatral
Application: Alfuzosin hydrochloride is an α 1 adrenoceptor antagonist
CAS Number: 81403-68-1
Purity: ≥99%
Molecular Weight: 425.91
Molecular Formula: C19H27N5O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Alfuzosin hydrochloride is a uro-selective α 1 adrenoceptor antagonist that does not distinguish between α 1 subtypes. In addition, in vitro studies indicate that Alfuzosin hydrochloride can relax corpus cavernosum tissue. Also Alfuzosin hydrochloride has been seen to inhibit the increase of intraurethral pressure caused by phenylephrine. Studies suggest that isocratic reversed phase high-performance liquid chromatographic (HPLC) with ultraviolet detection at 245 nm can be used, along with a stainless steel analytical column to determine the presence of Alfuzosin hydrochloride in solution. Furthermore, alternate studies indicate that Alfuzosin hydrochloride can be detected in human plasma using a spectrofluorimetric method which relies on measuring the native fluorescence of Alfuzosin hydrochloride in deionized water using λ excitation at 325.0 nm and λ emission at 390.0 nm along with solid phase extraction.


References

1. Fayed, A.S., et al. 2007. Pharmazie. 62: 830-835. PMID: 18065098
2. Ganesh, M., et al. 2009. Pak J Pharm Sci. 22: 263-266. PMID: 19553171

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (85 mg/ml at 25° C), methanol, ethanol (85 mg/ml at 25° C), and PBS (pH 7.2) (~1 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
230-232° C
Refractive Index :
n20D 1.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
Merck Index :
14: 238
MDL Number :
MFCD00879135
Beilstein Registry :
6034829
SMILES :
CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Relevant assays for usage as analytical standards Relevant assays for usage as analytical standards.
Date published: 2015-06-08
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