Alexidine dihydrochlorideAn antibacterial and anti-plaque agent

Alexidine dihydrochloride (CAS 1715-30-6)

Alexidine dihydrochloride | CAS 1715-30-6 is rated 5.0 out of 5 by 1.
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Synonym: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide
Application: An antibacterial and anti-plaque agent
CAS Number: 1715-30-6
Molecular Weight: 581.71
Molecular Formula: C26H56N102HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Alexidine Dihydrochloride is an antibacterial and antiplaque agent against Streptococcus mutans, Actinomyces viscosus, and Actinomyces naesludii. In addition, Alexidine Dihydrochloride inhibits the activity of GtfB in solution and on the surface of SHA beads. Furthermore, studies involving DNA content analysis and electron microscopy show that Alexidine Dihydrochloride induces apoptosis by causing mitochondrial damage and membrane depolarization which leads to a loss in cell membrane integrity. This compound is a selective inhibitor of PTPMT1 (protein tyrosine phosphatases localized to mitochondrion 1) with an IC50 = 1.08 μM in vitro. Alexidine Dihydrochloride is an inhibitor od PLB.


References

1. Pinzauti, S., et al. 1979. J Pharm Belg. 34: 101-103. PMID: 512819
2. Yip, K.W., et al. 2006. Mol. Cancer Ther. 5: 2234-2240. PMID: 16985057

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in Methanol (100mg/4ml)
Storage :
Store at -20° C
Melting Point :
220-224° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
102678
MDL Number :
MFCD00082369
SMILES :
CCCCC(CC)CN=C(N)NC(=NCCCCCCN=C(N)NC(=NCC(CC)CCCC)N)N.Cl.Cl

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Certificate of Analysis

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Alexidine dihydrochloride  Product Citations

See how others have used Alexidine dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25139679  Ruiz-Linares, M. et al. 2014. Ann. Clin. Microbiol. Antimicrob. 13: 41.

PMID: # 22495680  Elder, BL. et al. 2012. Eye Contact Lens. 38: 222-6.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Yip et al Yip et al. (PubMed ID 16985057) found that alexidine dihydrochloride induced apoptosis by inducing mitochondrial damage in cancer cells. -SCBT Publication Review
Date published: 2015-05-06
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