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Alendronate, Sodium Salt is a nitrogen-containing bisphosphate that acts as a robust inhibitor of bone reabsorption and induces apoptosis in osteoclasts, among other cell types, by modification of GTP-binding proteins post-transcriptionally. The compound has been shown to act as a selective inhibitor of FDPS (farnesyl diphosphate synthase). Prostate cancer studies also revealed that Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.
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See how others have used Alendronate, Sodium Salt. Click on the entry to view the PubMed entry .
PMID: # 9874784 Fisher, JE. et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 133-138.
PMID: # 8950879 Black, DM. et al. 1996. Lancet. 348: 1535-1541.
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