Alendronate, Sodium SaltA robust inhibitor of bone resorption that induces apoptosis

Alendronate, Sodium Salt (CAS 121268-17-5)

Alendronate, Sodium Salt | CAS 121268-17-5 is rated 5.0 out of 5 by 1.
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Application: A robust inhibitor of bone resorption that induces apoptosis
CAS Number: 121268-17-5
Purity: ≥99%
Molecular Weight: 325.1
Molecular Formula: C4H12NNaO7P2 3H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Alendronate, Sodium Salt is a nitrogen-containing bisphosphate that acts as a robust inhibitor of bone reabsorption and induces apoptosis in osteoclasts, among other cell types, by modification of GTP-binding proteins post-transcriptionally. The compound has been shown to act as a selective inhibitor of FDPS (farnesyl diphosphate synthase). Prostate cancer studies also revealed that Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.


References

1. Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373: 231-241. PMID: 10620343
2. Virtanen, S.S., et al. 2002. Cancer Res. 62: 2708-2714. PMID: 11980672
3. Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 61: 1255-1262. PMID: 11961144
4. Ma, Y.L., et al. 2003. Endocrinology. 144: 2008-2015. PMID: 12697709

Physical State :
Solid
Solubility :
Soluble in water (40 g/l) at 25° C, and PBS (pH 7.2) (~0.25 mg/ml).
Storage :
Store at 4° C
Melting Point :
250-280° C (dec.)
Boiling Point :
616.7° C at 760 mmHg (Predicted)
IC50 :
farnesyl diphosphate synthase: IC50 = 460 nM; broad-spectrum MMP: IC50 = ~ 40 - 70 µM; invasion of prostate cancer cells: IC50 = ~ 1 pM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SZ6523500
PubChem CID :
23681107
Merck Index :
14: 229
MDL Number :
MFCD01748233
EC Number :
601-766-4
Beilstein Registry :
6947932
SMILES :
C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+]

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Certificate of Analysis

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Alendronate, Sodium Salt  Product Citations

See how others have used Alendronate, Sodium Salt. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 9874784  Fisher, JE. et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 133-138.

PMID: # 8950879  Black, DM. et al. 1996. Lancet. 348: 1535-1541.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Fisher et al Fisher et al. (PubMed ID 9874784) found that alendronate inhibited murine osteoclast formation in culture and activated a 34-kDa kinase. -SCBT Publication Review
Date published: 2015-06-15
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