Akt1/2 kinase inhibitor Inhibitor

5.0(1)

Alternate Names: 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one trifluoroacetate salt ; Akt Inhibitor VIII trifluoroacetate salt ; Akti-1/2 trifluoroacetate salt

Application: Akt1/2 kinase inhibitor is an Isozyme selective Akt1/2 kinase inhibitor

Purity: ≥98%

Molecular Weight: 683.69

Molecular Formula: C₃₆H₃₂F₃N₇O₄•xC₂HF₃O₂

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Akt1/2 kinase inhibitor is an Isozyme selective Akt1/2 kinase inhibitor. In in vitro kinase assays, this shows IC₅₀ = 58 nM, 210 nM, and 2.12 mM for Akt1, Akt2, and Akt3. The inhibition appears to be pleckstrin homology (PH) domain-dependent and the Akt1/2 kinase inhibitor has no inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 μM.

References

1. Zhao, Z. 2005. Bioorg. Med. Chem. Lett. 15(4): 905-909. PMID: 15686884 2. Barnett, S.F. 2005. Biochem. J. 385(Pt 2): 399-408. PMID: 15456405

Appearance :

Powder

Physical State :

Solid

Solubility :

Soluble in DMSO ( ≥10 mg/mL).

Storage :

Store at 4° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

16218954

MDL Number :

MFCD08705407

SMILES :

C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7.C(=O)(C(F)(F)F)O.O

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Certificate of Analysis

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