Akt1/2 kinase inhibitor Inhibitor Akt1/2 kinase inhibitor is an Isozyme selective Akt1/2 kinase inhibitor.

Akt1/2 kinase inhibitor Inhibitor

Akt1/2 kinase inhibitor is rated 5.0 out of 5 by 1.
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Alternate Names: 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one trifluoroacetate salt ; Akt Inhibitor VIII trifluoroacetate salt ; Akti-1/2 trifluoroacetate salt
Application: Akt1/2 kinase inhibitor is an Isozyme selective Akt1/2 kinase inhibitor
Purity: ≥98%
Molecular Weight: 683.69
Molecular Formula: C36H32F3N7O4•xC2HF3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Akt1/2 kinase inhibitor is an Isozyme selective Akt1/2 kinase inhibitor. In in vitro kinase assays, this shows IC50 = 58 nM, 210 nM, and 2.12 mM for Akt1, Akt2, and Akt3. The inhibition appears to be pleckstrin homology (PH) domain-dependent and the Akt1/2 kinase inhibitor has no inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 μM.


References

1. Zhao, Z. 2005. Bioorg. Med. Chem. Lett. 15(4): 905-909. PMID: 15686884 2. Barnett, S.F. 2005. Biochem. J. 385(Pt 2): 399-408. PMID: 15456405

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO ( ≥10 mg/mL).
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD08705407
SMILES :
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7.C(=O)(C(F)(F)F)O.O

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Certificate of Analysis

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Akt1/2 kinase inhibitor Inhibitor  Product Citations

See how others have used Akt1/2 kinase inhibitor Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 30886861  Tsai, FM.|Li, CH.|Wang, LK.|Chen, ML.|Lee, MC.|Lin, YY.|Wang, CH.| et al. 2019. Biomed Res Int. 2019: 6360503.

PMID: # 29992246  Wang, D. et al. 2018. Endocrinology. 159: 3132-3142.

PMID: # 32427102  Elife. 9:

PMID: # 31432194  Mol Med Rep. 20: 3719-3727.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Barnett et al Barnett et al. (PubMed ID 15456405) found that Akt1/2 kinase inhibitor blocked phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells and promoted TRAIL-induced apoptosis in LNCap prostate cancer cells. -SCBT Publication Review
Date published: 2015-04-26
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