Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 MF: C40H43N7O2 3HCl
MW: 763.2
A cell-permeable and water soluble analog of Akt Inhibitor VIII.

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2

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Application: Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 is a cell-permeable and water soluble analog of Akt Inhibitor VIII
Molecular Weight: 763.2
Molecular Formula: C40H43N7O2 3HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Akt Inhibitor XIII, Isozyme-Selective, Akti-1/2 is a highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (sc-202048) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC50 = 560 nM, 390 nM and 7.8 μM in an in vitro kinase assay; 526 nM, 730 nM and > 10 μM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC50 > 50 μM). One of the compounds potent regioisomers (C7-substituted) is shown to enhance induced caspase-3 activity in several tumor cells.

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and water (50 mg/ml).
Storage :
Store at 4° C
IC50 :
Akt2: IC50 = 390 nM (kinase assay (in vitro)); Akt1: IC50 = 526 nM (LNCaP cells); Akt1: IC50 = 560 nM (kinase assay (in vitro)); Akt2: IC50 = 730 nM (LNCaP cells); Akt3: IC50 = 7.8 µM (kinase assay (in vitro))
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Certificate of Analysis

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Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2  Product Citations

See how others have used Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24762137  Coomans de Brachène, A. et al. 2014. The Biochemical journal. 460: 25-34.

Citations 1 to 1 of 1 total
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