Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2

(0)

Application: Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 is a cell-permeable and water soluble analog of Akt Inhibitor VIII

Molecular Weight: 763.2

Molecular Formula: C₄₀H₄₃N₇O₂ ₃HCl

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

QUICK LINKS

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2: sc-221231...

Click on image or enlarge button to enlarge

Akt Inhibitor XIII, Isozyme-Selective, Akti-1/2 is a highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (sc-202048) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC₅₀ = 560 nM, 390 nM and 7.8 μM in an in vitro kinase assay; 526 nM, 730 nM and > 10 μM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC₅₀ > 50 μM). One of the compounds potent regioisomers (C7-substituted) is shown to enhance induced caspase-3 activity in several tumor cells.

Physical State :

Solid

Solubility :

Soluble in DMSO (25 mg/ml), and water (50 mg/ml).

Storage :

Store at 4° C

IC50 :

Akt2: IC₅₀ = 390 nM (kinase assay (in vitro)); Akt1: IC₅₀ = 526 nM (LNCaP cells); Akt1: IC₅₀ = 560 nM (kinase assay (in vitro)); Akt2: IC₅₀ = 730 nM (LNCaP cells); Akt3: IC₅₀ = 7.8 µM (kinase assay (in vitro))

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents