Akt Inhibitor XII, Isozyme-Selective, Akti-2 MF: C39H39N7O2 3HCl
MW: 747.17
A cell-permeable Akt1/2 inhibitor with improved solubility and Ak2 selectivity.

Akt Inhibitor XII, Isozyme-Selective, Akti-2

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Application: Akt Inhibitor XII, Isozyme-Selective, Akti-2 is a cell-permeable Akt1/2 inhibitor with improved solubility and Ak2 selectivity
Purity: ≥97%
Molecular Weight: 747.17
Molecular Formula: C39H39N7O2 3HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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A cell-permeable Akti-1/2- (sc-202048) derived allosteric inhibitor pair (1:1 regioisomeric mixture) with much improved aqueous solubility (10 mg/ml in a pH 7.4 saline) and Akt2 selectivity (IC50 = 805 nM for Akt2, >10 µM for Akt1/3, and >50 µM for PKA/PKC/SGK). The inhibition is PH domain-dependent and non-competitive with ATP.


References

1. Zhao, Z., Robinson, R.G., Barnett, S.F., Defeo-Jones, D., Jones, R.E., Hartman, G.D., Huber, H.E., Duggan, M.E. and Lindsley, C.W. 2008. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg. Med. Chem. Lett. 18(1): 49-53. PMID: 18054229

Physical State :
Solid
Solubility :
Soluble in DMSO or Water
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

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